基于分子内电荷转移增强策略的 MAO-A 特异性双光子荧光探针用于脑胶质瘤细胞/组织成像。
Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma cell/tissue imaging.
机构信息
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, P. R. China.
Department of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, P. R. China.
出版信息
Chem Commun (Camb). 2021 Oct 26;57(85):11260-11263. doi: 10.1039/d1cc04744b.
MAO-A promotes the proliferation of human glioma cells. Herein, we report a series of MAO-A specific two-photon small molecular fluorescent probes (A1-5) based on an intramolecular charge transfer enhancing strategy. The activity of endogenous MAO-A can be selectively imaged using A3 as a representative probe in different biological samples including human glioma cells/tissues two-photon fluorescence microscopy. The study provides new tools for the visual detection of glioma.
MAO-A 促进人神经胶质瘤细胞的增殖。在此，我们报告了一系列基于分子内电荷转移增强策略的 MAO-A 特异性双光子小分子荧光探针（A1-5）。可以使用 A3 作为代表性探针，在包括人神经胶质瘤细胞/组织在内的不同生物样品中，通过双光子荧光显微镜术，对内源性 MAO-A 的活性进行选择性成像。该研究为神经胶质瘤的可视化检测提供了新工具。
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