Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
Exp Cell Res. 2021 Nov 15;408(2):112859. doi: 10.1016/j.yexcr.2021.112859. Epub 2021 Oct 9.
Angiogenesis plays a pivotal role in cancer initiation, maintenance, and progression. Diet may inhibit, retard or reverse these processes affecting angiogenesis (angioprevention). Nutraceuticals, such as omega-3 fatty acids, amino acids, proteins, vitamins, minerals, fibers, and phenolic compounds, improve health benefits as they are a source of bioactive compounds that, among other effects, can regulate angiogenesis. The literature concerning the pro-angiogenic and/or anti-angiogenic nutraceuticals and the possible activated pathways in cancer and other non-neoplastic diseases by in vivo and in vitro experiments are reviewed.
血管生成在癌症的发生、维持和进展中起着关键作用。饮食可能会抑制、延缓或逆转这些影响血管生成的过程（血管预防）。营养保健品，如ω-3 脂肪酸、氨基酸、蛋白质、维生素、矿物质、纤维和酚类化合物，因其是生物活性化合物的来源而具有改善健康的益处，这些生物活性化合物除其他作用外，还可以调节血管生成。本文综述了体内和体外实验中关于促血管生成和/或抗血管生成的营养保健品，以及它们在癌症和其他非肿瘤性疾病中可能激活的途径。
