Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University, Seoul, South Korea.
Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University, Seoul, South Korea.
J Biol Chem. 2021 Nov;297(5):101296. doi: 10.1016/j.jbc.2021.101296. Epub 2021 Oct 9.
Adipose tissue dysfunction is a hallmark of obesity and contributes to obesity-related sequelae such as metabolic complications and insulin resistance. Compelling evidence indicates that adipose-tissue-specific gene expression is influenced by gene interactions with proximal and distal cis-regulatory elements; the latter exert regulatory effects via three-dimensional (3D) chromosome conformation. Recent advances in determining the regulatory mechanisms reveal that compromised epigenomes are molecularly interlinked to altered cis-regulatory element activity and chromosome architecture in the adipose tissue. This review summarizes the roles of epigenomic components, particularly DNA methylation, in transcriptional rewiring in adipose tissue. In addition, we discuss the emerging roles of DNA methylation in the maintenance of 3D chromosome conformation and its pathophysiological significance concerning adipose tissue function.
脂肪组织功能障碍是肥胖的一个标志，并导致肥胖相关的后果，如代谢并发症和胰岛素抵抗。有强有力的证据表明，脂肪组织特异性基因表达受到基因与近端和远端顺式调控元件相互作用的影响；后者通过三维（3D）染色体构象发挥调节作用。最近在确定调控机制方面的进展表明，受损的表观基因组与脂肪组织中顺式调控元件活性和染色体结构的改变在分子上相互关联。这篇综述总结了表观基因组成分，特别是 DNA 甲基化，在脂肪组织转录重编程中的作用。此外，我们还讨论了 DNA 甲基化在维持 3D 染色体构象及其与脂肪组织功能相关的病理生理意义方面的新兴作用。
