Fujimoto H, Ikeda K, Yamamoto K, Taguchi S, Shirakawa K
Jpn J Antibiot. 1986 Jun;39(6):1607-11.
A new carbapenem antibiotic and renal dipeptidase inhibitor, imipenem/cilastatin sodium (MK-0787/MK-0791) were studied for the distribution into various tissues and for clinical aspects in obstetrical and gynecological fields. The following results were obtained. Concentrations of the drug in arterial blood, venous blood, and internal genital organs following an intravenous drip infusion were measured. The results demonstrated good transfer of the drug into various internal genital organs. Four patients with bacterial infections were treated with MK-0787/MK-0791. Therapeutic results were good in 2 cases for, an effective rate of 50%. No side effects were noted in any cases. The above results suggested that MK-0787/MK-0791 may be a useful antibiotic for infectious diseases in the field of obstetrics and gynecology.
一种新型碳青霉烯类抗生素及肾二肽酶抑制剂亚胺培南/西司他丁钠（MK - 0787/MK - 0791），针对其在各种组织中的分布以及在妇产科领域的临床应用进行了研究。获得了以下结果。测定了静脉滴注后动脉血、静脉血及内生殖器官中的药物浓度。结果表明该药物能良好地转运至各种内生殖器官。4例细菌感染患者接受了MK - 0787/MK - 0791治疗。2例治疗效果良好，有效率为50%。所有病例均未观察到副作用。上述结果表明，MK - 0787/MK - 0791可能是妇产科领域治疗传染病的一种有效抗生素。
