Oprandi Maria Chiara, Oldrati Viola, Cavatorta Claudia, Gandola Lorenza, Massimino Maura, Bardoni Alessandra, Poggi Geraldina
Neuro-Oncological and Neuropsychological Rehabilitation Unit, Scientific Institute, IRCCS E. Medea, 23842 Bosisio Parini, Italy.
Medical Physics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.
Cancers (Basel). 2022 Jun 23;14(13):3075. doi: 10.3390/cancers14133075.
(1) Background: The relationship between processing speed (PS) and psychological adjustment in the healthy population is well established, as is that between low socio-economic status (SES) and psychological distress. While PS is one of the most impaired functions in pediatric brain tumor survivors (PBTSs), previous research has demonstrated that low SES may be a predictor of increased psychosocial risk in PBTSs. Given the psychological adjustment difficulties observed in PBTS, in the current study we aimed to explore the relationship between SES and psychological functioning, considering the contribution of PS as a mediator. (2) Methods: demographic and clinical data of 80 children (age range: 4-17 y.o.) were retrospectively collected. Psychological measures were the parent-compiled versions of the Child Behavioral Checklist (CBCL) and the Strengths and Difficulties Questionnaire (SDQ). Mediation analysis models were performed on psychological measures with and without the inclusion of covariates. (3) Results: The influence of SES on the CBCL total index was mediated by PS. Furthermore, PS was found to have a mediating effect on the relationship between SES and internalizing problems but not on the relationship between SES and externalizing problems. (4) Conclusions: The results suggest that PS may be a rehabilitation target for the prevention of psychological distress and should be addressed especially for PBTSs who live in a disadvantaged situation.
(1) 背景：在健康人群中，处理速度（PS）与心理调适之间的关系已得到充分确立，社会经济地位（SES）较低与心理困扰之间的关系也是如此。虽然PS是小儿脑肿瘤幸存者（PBTSs）中受损最严重的功能之一，但先前的研究表明，低SES可能是PBTSs心理社会风险增加的一个预测因素。鉴于在PBTS中观察到的心理调适困难，在本研究中，我们旨在探讨SES与心理功能之间的关系，同时考虑PS作为中介变量的作用。(2) 方法：回顾性收集了80名儿童（年龄范围：4至17岁）的人口统计学和临床数据。心理测量工具为家长编制版的儿童行为清单（CBCL）和优势与困难问卷（SDQ）。在纳入和不纳入协变量的情况下，对心理测量结果进行中介分析模型。(3) 结果：SES对CBCL总指数的影响通过PS进行中介。此外，发现PS对SES与内化问题之间的关系有中介作用，但对SES与外化问题之间的关系没有中介作用。(4) 结论：结果表明，PS可能是预防心理困扰的一个康复目标，对于处于不利处境的PBTS尤其应予以关注。
