Peek Mirjam C L, Saeki Kohei, Ohashi Kaichi, Chikaki Shinichi, Baker Rose, Nakagawa Takayuki, Kusakabe Moriaki, Douek Michael, Sekino Masaki
Division of Cancer Studies, King's College London, London SE1 9RT, UK.
Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, Japan.
Cancers (Basel). 2021 Oct 8;13(19):5031. doi: 10.3390/cancers13195031.
The magnetic technique, consisting of a magnetic tracer and a handheld magnetometer, is a promising alternative technique for sentinel lymph node dissection (SLND) and was shown to be non-inferior to the standard technique in terms of identification rates. In this study, injection characteristics (iron dose, dilution, time course and massaging) were evaluated to optimize magnetic tracer uptake in the sentinel lymph nodes (SLN) in a rat hindleg model. 202 successful SLNDs were performed. Iron uptake in the SLN is proportional (10% utilization rate) to the injection dose between 20 and 200 μg, showing a plateau uptake of 80 μg in the SLN around 1000 μg injection. Linear regression showed that time had a higher impact than dilution, on the SLN iron uptake. Massaging showed no significant change in iron uptake. The amount of residual iron at the injection site was also proportional to the injection dose without any plateau. Time was a significant factor for wash-out of residual iron. From these results, preoperative injection may be advantageous for SLN detection as well as reduction in residual iron at the injection site by potential decrease in required injection dose.
由磁性示踪剂和手持式磁力计组成的磁性技术，是一种用于前哨淋巴结清扫术（SLND）的有前景的替代技术，并且在识别率方面已被证明不劣于标准技术。在本研究中，在大鼠后肢模型中评估了注射特性（铁剂量、稀释度、时间进程和按摩），以优化前哨淋巴结（SLN）对磁性示踪剂的摄取。进行了202次成功的SLND。SLN中的铁摄取与20至200μg之间的注射剂量成正比（利用率为10%），在注射约1000μg时，SLN中的摄取量达到80μg的平台期。线性回归表明，时间对SLN中铁摄取的影响比稀释度更大。按摩对铁摄取无显著影响。注射部位的残留铁量也与注射剂量成正比，没有任何平台期。时间是残留铁清除的一个重要因素。根据这些结果，术前注射可能有利于SLN检测，以及通过潜在降低所需注射剂量来减少注射部位的残留铁。
