Department of Biochemistry, Nihon University School of Medicine, Tokyo 173-8610, Japan.
Pathology Division, Shizuoka Cancer Center, Shizuoka 411-8777, Japan.
Int J Mol Sci. 2021 Sep 26;22(19):10349. doi: 10.3390/ijms221910349.
Periodontal inflammation is a common inflammatory disease associated with chronic inflammation that can ultimately lead to alveolar attachment loss and bone destruction. Understanding autophagy and pyroptosis has suggested their significant roles in inflammation. In recent years, studies of differentiated embryo-chondrocyte expressed genes 1 and 2 (Dec1 and Dec2) have shown that they play important functions in autophagy and in pyroptosis, which contribute to the onset of periodontal inflammation. In this review, we summarize recent studies on the roles of clock genes, including Dec1 and Dec2, that are related to periodontal inflammation and other diseases.
牙周炎是一种常见的炎症性疾病，与慢性炎症有关，最终可导致牙槽附着丧失和骨破坏。自噬和细胞焦亡的研究表明它们在炎症中具有重要作用。近年来，分化胚胎软骨细胞表达基因 1 和 2（Dec1 和 Dec2）的研究表明，它们在自噬和细胞焦亡中发挥重要作用，从而导致牙周炎的发生。本综述总结了与牙周炎和其他疾病相关的时钟基因（包括 Dec1 和 Dec2）在牙周炎中的作用的最新研究。
