• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

H.Lév 叶提取物对结扎诱导大鼠牙周炎的抗牙周病作用。

Anti-Periodontitis Effects of H.Lév Leaf Extract on Ligature-Induced Periodontitis in Rats.

机构信息

College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.

Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Republic of Korea.

出版信息

Molecules. 2023 Jan 14;28(2):849. doi: 10.3390/molecules28020849.

DOI:10.3390/molecules28020849
PMID:36677905
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9862488/
Abstract

Periodontitis is caused by pathogens in the oral cavity. It is a chronic infectious disease that causes symptoms including gingival bleeding and tooth loss resulting from the destruction of periodontal tissues coupled with inflammation. H.Lév (DM) is a natural product that exhibits various biological activities with few side effects. In this study, the potential of DM leaf hot-water extracts (DMWE) as a treatment for periodontitis was determined and its anti-oxidant and anti-inflammatory effects were evaluated. Compounds in DMWE were identified by high-performance liquid chromatography (HPLC) and nitric oxide (NO) and prostaglandin E (PGE) production was measured in RAW 264.7 cells. We measured the gingival index and gingival sulcus depth, and micro-CT was performed in vivo using a ligature-induced periodontitis rat model, which is similar to human periodontitis. The DMWE-treated group exhibited a decrease in cytokine concentration and relieved the gingival index and gingival sulcus depth compared with the periodontitis-induced control group. In addition, micro-CT and histological analysis revealed that DMWE exhibited anti-inflammatory effects and improved alveolar bone loss in periodontitis-induced rats. These findings suggest that DMWE has excellent anti-oxidant and anti-inflammatory effects that protect and prevent periodontal tissue damage and tooth loss caused by the inflammatory response.

摘要

牙周炎是由口腔中的病原体引起的。它是一种慢性传染病，会导致牙龈出血和牙齿脱落等症状，这是由于牙周组织的破坏和炎症所致。H.Lév（DM）是一种天然产物，具有多种生物活性，副作用较少。本研究旨在确定 DM 叶热水提取物（DMWE）作为治疗牙周炎的潜在用途，并评估其抗氧化和抗炎作用。通过高效液相色谱（HPLC）鉴定 DMWE 中的化合物，并在 RAW 264.7 细胞中测量一氧化氮（NO）和前列腺素 E（PGE）的产生。我们通过结扎诱导的牙周炎大鼠模型（类似于人类牙周炎）在体内测量了牙龈指数和牙龈沟深度。与牙周炎诱导的对照组相比，DMWE 处理组的细胞因子浓度降低，牙龈指数和牙龈沟深度得到缓解。此外，微 CT 和组织学分析表明，DMWE 具有抗炎作用，可改善牙周炎诱导大鼠的牙槽骨丢失。这些发现表明，DMWE 具有出色的抗氧化和抗炎作用，可保护和预防炎症反应引起的牙周组织损伤和牙齿脱落。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/00b21c67a230/molecules-28-00849-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/341a071947a9/molecules-28-00849-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/6d40d7cba6c3/molecules-28-00849-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/fdc752d08729/molecules-28-00849-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/e1e6c6a5f1be/molecules-28-00849-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/b0cd047b9308/molecules-28-00849-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/9070d7770264/molecules-28-00849-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/bfd67abc4cd5/molecules-28-00849-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/00b21c67a230/molecules-28-00849-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/341a071947a9/molecules-28-00849-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/6d40d7cba6c3/molecules-28-00849-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/fdc752d08729/molecules-28-00849-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/e1e6c6a5f1be/molecules-28-00849-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/b0cd047b9308/molecules-28-00849-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/9070d7770264/molecules-28-00849-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/bfd67abc4cd5/molecules-28-00849-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a153/9862488/00b21c67a230/molecules-28-00849-g008.jpg

相似文献

1
Anti-Periodontitis Effects of H.Lév Leaf Extract on Ligature-Induced Periodontitis in Rats.H.Lév 叶提取物对结扎诱导大鼠牙周炎的抗牙周病作用。
Molecules. 2023 Jan 14;28(2):849. doi: 10.3390/molecules28020849.
2
Anti-inflammatory, anti-osteoclastic, and antioxidant activities of genistein protect against alveolar bone loss and periodontal tissue degradation in a mouse model of periodontitis.染料木黄酮具有抗炎、抗破骨细胞和抗氧化活性，可防止牙周炎小鼠模型中牙槽骨丢失和牙周组织降解。
J Biomed Mater Res A. 2017 Sep;105(9):2510-2521. doi: 10.1002/jbm.a.36109. Epub 2017 Jun 6.
3
Quercetin Decreased Alveolar Bone Loss and Apoptosis in Experimentally Induced Periodontitis Model in Wistar Rats.槲皮素可减少实验性诱导牙周炎模型中 Wistar 大鼠的牙槽骨丢失和细胞凋亡。
Antiinflamm Antiallergy Agents Med Chem. 2020;19(4):436-448. doi: 10.2174/1871523019666200124114503.
4
Effect of paeonol on tissue destruction in experimental periodontitis of rats.丹皮酚对大鼠实验性牙周炎组织破坏的影响。
Am J Chin Med. 2014;42(2):361-74. doi: 10.1142/S0192415X14500244.
5
The histopathological and morphometric investigation of the effects of systemically administered humic acid on alveolar bone loss in ligature-induced periodontitis in rats.全身给药腐植酸对大鼠结扎诱导性牙周炎牙槽骨丧失影响的组织病理学和形态计量学研究
J Periodontal Res. 2016 Aug;51(4):499-507. doi: 10.1111/jre.12329. Epub 2015 Nov 7.
6
Green tea extract inhibits the onset of periodontal destruction in rat experimental periodontitis.绿茶提取物可抑制大鼠实验性牙周炎中牙周组织破坏的发生。
J Periodontal Res. 2014 Oct;49(5):652-9. doi: 10.1111/jre.12147.
7
Resveratrol prevents alveolar bone loss in an experimental rat model of periodontitis.白藜芦醇可预防实验性大鼠牙周炎模型中的牙槽骨丧失。
Acta Biomater. 2016 Jan;29:398-408. doi: 10.1016/j.actbio.2015.10.031. Epub 2015 Oct 20.
8
Antiperiodontitis Effects of Extract on Ligature-Induced Periodontitis in Rats.对大鼠结扎诱导性牙周炎的牙周炎防治作用的 提取物研究。
Nutrients. 2019 Apr 25;11(4):934. doi: 10.3390/nu11040934.
9
The histopathological and morphometric investigation of the effects of systemically administered boric acid on alveolar bone loss in ligature-induced periodontitis in diabetic rats.全身给药硼酸对糖尿病大鼠结扎诱导性牙周炎牙槽骨丧失影响的组织病理学和形态计量学研究
Acta Odontol Scand. 2014 Nov;72(8):729-36. doi: 10.3109/00016357.2014.898789. Epub 2014 Apr 11.
10
The effect of orally administered epigallocatechin-3-gallate on ligature-induced periodontitis in rats.表没食子儿茶素没食子酸酯对大鼠结扎诱导牙周炎的影响。
J Periodontal Res. 2013 Dec;48(6):781-9. doi: 10.1111/jre.12071. Epub 2013 Apr 15.

引用本文的文献

1
Therapeutic Effects of Hinokitiol through Regulating the SIRT1/NOX4 against Ligature-Induced Experimental Periodontitis.扁柏酚通过调控SIRT1/NOX4对结扎诱导的实验性牙周炎的治疗作用
Antioxidants (Basel). 2024 Apr 30;13(5):550. doi: 10.3390/antiox13050550.

本文引用的文献

1
ROS-scavenging biomaterials for periodontitis.用于牙周炎的活性氧清除生物材料。
J Mater Chem B. 2023 Jan 18;11(3):482-499. doi: 10.1039/d2tb02319a.
2
Current Concepts in the Management of Periodontitis.牙周炎治疗的现状。
Int Dent J. 2021 Dec;71(6):462-476. doi: 10.1111/idj.12630. Epub 2021 Feb 19.
3
The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation.Dec1 和 Dec2 在牙周炎炎症中的潜在作用。
Int J Mol Sci. 2021 Sep 26;22(19):10349. doi: 10.3390/ijms221910349.
4
Comparison of Oxidant Stress Levels among Healthy, Chronic Periodontitis, and Ischemic Heart Disease Subjects with Presence or Absence of Chronic Periodontitis.健康、慢性牙周炎以及伴有或不伴有慢性牙周炎的缺血性心脏病受试者氧化应激水平的比较。
Contemp Clin Dent. 2021 Apr-Jun;12(2):157-163. doi: 10.4103/ccd.ccd_192_20. Epub 2021 Jun 14.
5
In Vivo Evaluation of Leaf Extract for Anti-Obesity and Cholesterol-Lowering Activity in Mice.体内评价叶提取物对肥胖症和降胆固醇活性的影响。
Nutrients. 2021 Apr 23;13(5):1424. doi: 10.3390/nu13051424.
6
Mechanisms involved in regulation of periodontal ligament cell production of pro-inflammatory cytokines: Implications in periodontitis.参与调节牙周韧带细胞产生促炎细胞因子的机制：在牙周炎中的意义。
J Periodontal Res. 2021 Apr;56(2):249-255. doi: 10.1111/jre.12823. Epub 2020 Dec 10.
7
Adjunctive systemic antimicrobials for the non-surgical treatment of periodontitis.辅助性全身用抗菌药物用于牙周炎的非手术治疗
Cochrane Database Syst Rev. 2020 Nov 16;11(11):CD012568. doi: 10.1002/14651858.CD012568.pub2.
8
Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way.牙周炎是一种氧化应激相关的炎症性疾病：我们应该这样对待它。
Periodontol 2000. 2020 Oct;84(1):45-68. doi: 10.1111/prd.12342.
9
Flossing Is Associated with Improved Oral Health in Older Adults.用牙线洁牙与老年人的口腔健康改善相关。
J Dent Res. 2020 Aug;99(9):1047-1053. doi: 10.1177/0022034520916151. Epub 2020 Apr 22.
10
Periodontitis and cardiovascular diseases: Consensus report.牙周炎与心血管疾病：共识报告。
J Clin Periodontol. 2020 Mar;47(3):268-288. doi: 10.1111/jcpe.13189. Epub 2020 Feb 3.