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神经生长因子特异性 Trk 受体在食蚊鱼机械感觉系统中的定位。

Localization of Neurotrophin Specific Trk Receptors in Mechanosensory Systems of Killifish (.

机构信息

Zebrafish Neuromorphology Laboratory, Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.

出版信息

Int J Mol Sci. 2021 Sep 27;22(19):10411. doi: 10.3390/ijms221910411.

DOI:10.3390/ijms221910411
PMID:34638748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8508645/
Abstract

Neurotrophins (NTs) and their signal-transducing Trk receptors play a crucial role in the development and maintenance of specific neuronal subpopulations in nervous and sensory systems. NTs are supposed to regulate two sensory systems in fish, the inner ear and the lateral line system (LLS). The latter is one of the major mechanosensory systems in fish. Considering that annual fishes of the genus , with their short life expectancy, have become a suitable model for aging studies and that the occurrence and distribution of neurotrophin Trk receptors have never been investigated in the inner ear and LLS of killifish (), our study aimed to investigate the localization of neurotrophin-specific Trk receptors in mechanosensory systems of . For histological and immunohistochemical analysis, adult specimens of were processed using antibodies against Trk receptors and S100 protein. An intense immunoreaction for TrkA and TrkC was found in the sensory cells of the inner ear as well as in the hair cells of LLS. Moreover, also the neurons localized in the acoustic ganglia displayed a specific immunoreaction for all Trk receptors (TrkA, B, and C) analyzed. Taken together, our results demonstrate, for the first time, that neurotrophins and their specific receptors could play a pivotal role in the biology of the sensory cells of the inner ear and LLS of and might also be involved in the hair cells regeneration process in normal and aged conditions.

摘要

神经递（NT）及其信号转导的 Trk 受体在神经和感觉系统中特定神经元亚群的发育和维持中起着至关重要的作用。NT 被认为可以调节鱼类的两个感觉系统，内耳和侧线系统（LLS）。后者是鱼类的主要机械感觉系统之一。考虑到短寿命的一年生鱼类已成为衰老研究的合适模型，并且神经递 NT 特异性 Trk 受体在内耳和弹涂鱼（）的 LLS 中的发生和分布从未被研究过，我们的研究旨在调查神经递特定 Trk 受体在机械感觉系统中的定位。为了进行组织学和免疫组织化学分析，使用针对 Trk 受体和 S100 蛋白的抗体处理成年标本。在内耳的感觉细胞以及 LLS 的毛细胞中发现了 TrkA 和 TrkC 的强烈免疫反应。此外，定位于听神经节中的神经元也对所有分析的 Trk 受体（TrkA、B 和 C）表现出特异性免疫反应。总之，我们的结果首次表明，神经递及其特异性受体可能在 内耳和 LLS 的感觉细胞生物学中发挥关键作用，并且可能也参与正常和衰老条件下毛细胞的再生过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e8/8508645/01c08669d23c/ijms-22-10411-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e8/8508645/5c59d208a95b/ijms-22-10411-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e8/8508645/128f3f337977/ijms-22-10411-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e8/8508645/d5d4c38a8393/ijms-22-10411-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e8/8508645/890883fe4a35/ijms-22-10411-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e8/8508645/974152f086e8/ijms-22-10411-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e8/8508645/01c08669d23c/ijms-22-10411-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e8/8508645/5c59d208a95b/ijms-22-10411-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e8/8508645/128f3f337977/ijms-22-10411-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e8/8508645/c27d89c8d5ef/ijms-22-10411-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e8/8508645/921a3203312a/ijms-22-10411-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e8/8508645/6267e32e92bb/ijms-22-10411-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e8/8508645/d5d4c38a8393/ijms-22-10411-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e8/8508645/890883fe4a35/ijms-22-10411-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e8/8508645/974152f086e8/ijms-22-10411-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e8/8508645/01c08669d23c/ijms-22-10411-g009.jpg

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