Department of Plants, Soils and Climate, Utah State University, Logan, UT 84322, USA.
Bioinformatics Facility, Center for Integrated BioSystems, Utah State University, Logan, UT 84322, USA.
Int J Mol Sci. 2021 Oct 8;22(19):10897. doi: 10.3390/ijms221910897.
The genus comprises some of the most important and commonly cultivated fruit plants. Within the last decade, citrus greening disease (also known as huanglongbing or HLB) has emerged as the biggest threat for the citrus industry. This disease does not have a cure yet and, thus, many efforts have been made to find a solution to this devastating condition. There are challenges in the generation of high-yield resistant cultivars, in part due to the limited and sparse knowledge about the mechanisms that are used by the bacteria to proliferate the infection in plants. Here, we present GreeningDB, a database implemented to provide the annotation of proteomes, as well as the host-pathogen comparactomics tool, a novel platform to compare the predicted interactomes of two HLB host-pathogen systems. GreeningDB is built to deliver a user-friendly interface, including network visualization and links to other resources. We hope that by providing these characteristics, GreeningDB can become a central resource to retrieve HLB-related protein annotations, and thus, aid the community that is pursuing the development of molecular-based strategies to mitigate this disease's impact. The database is freely available at http://bioinfo.usu.edu/GreeningDB/ (accessed on 11 August 2021).
该属包括一些最重要和最常栽培的水果植物。在过去的十年中，柑橘黄龙病（也称为黄龙病或 HLB）已成为柑橘产业的最大威胁。这种疾病目前还没有治愈方法，因此，人们做出了许多努力来寻找解决这种破坏性疾病的方法。在产生高产量抗性品种方面存在挑战，部分原因是对细菌在植物中增殖感染所使用的机制的了解有限且稀疏。在这里，我们介绍了 GreeningDB，这是一个数据库，用于对蛋白质组进行注释，以及宿主-病原体比较基因组学工具，这是一个比较两个 HLB 宿主-病原体系统预测互作组的新平台。GreeningDB 旨在提供用户友好的界面，包括网络可视化和到其他资源的链接。我们希望通过提供这些特性，GreeningDB 可以成为检索与 HLB 相关的蛋白质注释的中心资源，从而帮助正在寻求开发基于分子的策略来减轻这种疾病影响的社区。该数据库可免费在 http://bioinfo.usu.edu/GreeningDB/ 获得（访问时间为 2021 年 8 月 11 日）。
