Swiderska D, Buczko W, Wiśniewski K
Pol J Pharmacol Pharm. 1986 Jan-Feb;38(1):29-39.
The participation of prostaglandins (PGs) E2 and F2 alpha administered icv in the action of fibrinopeptides A and B (FAB) on the central dopamine neurons was investigated. PGE2 and PGF2 alpha (0.5 microgram) attenuated the intensity of apomorphine (APO)-induced stereotypy and completely abolished the stimulatory action of FAB. PGE2 given together with FAB attenuated, while PGF2 alpha did not affect the amphetamine-induced stereotypy and haloperidol-induced catalepsy. The investigated PGs did not affect or normalized the level of dopamine depressed by peptides in some parts of the brain. The results indicate that PGE2 alpha and PGF2 alpha do not participate in the mechanism of the central action of FAB.
研究了脑室内注射前列腺素（PGs）E2和F2α在纤维蛋白肽A和B（FAB）对中枢多巴胺神经元作用中的参与情况。PGE2和PGF2α（0.5微克）减弱了阿扑吗啡（APO）诱导的刻板行为的强度，并完全消除了FAB的刺激作用。PGE2与FAB一起给药可减弱，而PGF2α不影响苯丙胺诱导的刻板行为和氟哌啶醇诱导的僵住症。所研究的PGs在大脑某些部位对肽类降低的多巴胺水平没有影响或使其恢复正常。结果表明，PGE2α和PGF2α不参与FAB中枢作用的机制。
