某些前列腺素在纤维蛋白原降解产物（FDP）与大鼠中枢多巴胺受体相互作用中的作用。
The role of some prostaglandins in the interaction of fibrinogen degradation products (FDP) with central dopamine receptors of rats.
作者信息
Buczko W, Wiśniewski K
出版信息
Pol J Pharmacol Pharm. 1979 Sep-Oct;31(5):473-80.
Indomethacin and fibrinogen degradation products (FDP) augmented amphetamine and apomorphine-induced stereotypies. In contrast, PGE1 and PGE2 decreased the stereotypies in rats, while PGF2 alpha enhanced amphetamine-induced stereotypy. Indomethacin given in combination with the peptides did not change their effect, whereas prostaglandins diminished the stimulatory effect of FDP on the amphetamine or apomorphine-induced stereotypy. Indomethacin and studied prostaglandins did not influence inhibitory action of FDP on haloperidol-induced catalepsy. It is concluded that prostaglandins do not play any essential role in the interaction of FDP with dopaminergic system in the CNS.
吲哚美辛和纤维蛋白原降解产物（FDP）增强了苯丙胺和阿扑吗啡诱导的刻板行为。相比之下，前列腺素E1和前列腺素E2减少了大鼠的刻板行为，而前列腺素F2α增强了苯丙胺诱导的刻板行为。吲哚美辛与这些肽联合使用并没有改变它们的作用，而前列腺素减弱了FDP对苯丙胺或阿扑吗啡诱导的刻板行为的刺激作用。吲哚美辛和所研究的前列腺素并不影响FDP对氟哌啶醇诱导的僵住症的抑制作用。得出的结论是，前列腺素在中枢神经系统中FDP与多巴胺能系统的相互作用中不发挥任何重要作用。
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