Wawrzyniuk I, Buczko W, Wiśniewski K
Pol J Pharmacol Pharm. 1979 Jul-Aug;31(4):365-72.
The effect of fibrinopeptides A and B (FAB) on the action of compounds affecting the dopaminergic receptors in central nervous system (CNS) of rats was investigated. These peptides given intraperitoneally (ip) or intraventricularly (ivc) exerted dose-dependent stimulatory effects on the CNS: Enhanced the apomorphine and amphetamine-induced stereotypies and reduced the catalepsy induced by haloperidol. FAB depressed the dopamine level, especially when given together with alpha-MT, and elevated the level of homovanillic acid in the striatum. The results suggest that the stimulatory effects of FAB depend on their interaction with dopaminergic receptors in the CNS.
研究了纤维蛋白肽A和B（FAB）对影响大鼠中枢神经系统（CNS）多巴胺能受体的化合物作用的影响。这些肽经腹腔内（ip）或脑室内（ivc）给药后对中枢神经系统产生剂量依赖性刺激作用：增强阿扑吗啡和苯丙胺诱导的刻板行为，并减轻氟哌啶醇诱导的僵住症。FAB降低了多巴胺水平，尤其是与α-MT一起给药时，并提高了纹状体中高香草酸的水平。结果表明，FAB的刺激作用取决于它们与中枢神经系统中多巴胺能受体的相互作用。
