Division of Neurology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Department of Obstetrics and Gynecology, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Int J Environ Res Public Health. 2021 Sep 30;18(19):10342. doi: 10.3390/ijerph181910342.
The associations between gestational Bell's palsy (GBP) and late obstetric complications (LOCs), i.e., preeclampsia (PE), eclampsia (EC), gestational hypertension (GHT), and gestational diabetes mellitus (GDM) remain unclear. This study aimed to evaluate these associations and the neonatal health of the newborns born from pregnant women with and without GBP. A retrospective 1:5 case-control study matching exact maternal age and gravidity between pregnant women with and without GBP in Songklanagarind Hospital from 2006 to 2016 was conducted. The associations between GBP and PE, EC, GHT, and GDM, as well as comparison of the newborns' health indices were analyzed by bivariate analysis ( < 0.05). Eight GBP cases out of 8,756 pregnant women were recruited. Six GBP cases were first or second gravid. GBP occurred during the third trimester in five cases. Except for higher median systolic blood pressure (125 (114.2, 127.5) vs. (110 (107.0, 116.0), = 0.045) and diastolic blood pressures (77 (73.0, 80.8) vs. 70 (65.0, 73.2), = 0.021) in the GBP cases, associations between GBP and all LOCs could not be concluded due to the lack of power. However, a significantly lower mean birth weight in the newborns of GBP mothers was found (2672.2 (744.0) vs. 3154.8 (464.7), = 0.016) with statistically significant power. Except for the higher blood pressures and lower birth weights of the newborns of GBP mothers, an association between GBP and LOCs remains inconclusive.
妊娠贝尔氏麻痹(GBP)与晚期产科并发症(LOCs),即子痫前期(PE)、子痫(EC)、妊娠高血压(GHT)和妊娠糖尿病(GDM)之间的关联尚不清楚。本研究旨在评估这些关联以及患有和不患有 GBP 的孕妇所生新生儿的新生儿健康状况。对 2006 年至 2016 年在 Songklanagarind 医院就诊的患有和不患有 GBP 的孕妇进行了回顾性 1:5 病例对照研究,匹配了 exact 母亲年龄和孕次。通过二元分析(<0.05)分析了 GBP 与 PE、EC、GHT 和 GDM 之间的关联,以及新生儿健康指数的比较。从 8756 名孕妇中招募了 8 名 GBP 病例。6 例 GBP 病例为初产妇或经产妇。5 例 GBP 发生在孕晚期。除了 GBP 病例的收缩压中位数较高(125(114.2,127.5)比(110(107.0,116.0),=0.045)和舒张压中位数较高(77(73.0,80.8)比 70(65.0,73.2),=0.021)外,由于缺乏统计学效能,无法得出 GBP 与所有 LOCs 之间存在关联的结论。然而,GBP 母亲的新生儿的平均出生体重明显较低(2672.2(744.0)比 3154.8(464.7),=0.016),且具有统计学意义。除了 GBP 母亲的新生儿血压较高和出生体重较低外,GBP 与 LOCs 之间的关联仍不确定。