Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong, China.
Tasmanian School of Medicine, University of Tasmania, Hobart, TAS 7005, Australia.
Int J Environ Res Public Health. 2021 Oct 8;18(19):10541. doi: 10.3390/ijerph181910541.
Vasovagal reaction (VVR) compromises donor safety and reduces the subsequent return rates. Performing applied muscle tension (AMT) during phlebotomy may reduce the incidence of VVR. However, the effectiveness of performing AMT after phlebotomy to reduce delayed VVR remains unclear. With ethics approval, 12 young, first-time donors (YFTD) were recruited to study the effects on stroke volume (SV), cardiac output (CO) and systemic vascular resistance (SVR) while performing AMT from needle insertion to end of recovery. Measurements from 12 matched control YFTD were used for comparison. Pre-donation anxiety and VVR severity were assessed. Compared to controls, donors who performed AMT had higher SV (Control: 57 mL vs. AMT: 69 mL, = 0.045), higher CO (Control: 3.7 L·min vs. AMT: 5.2 L·min, = 0.006) and lower SVR (Control: 1962 dyn·s·cm vs. AMT: 1569 dyn·s·cm, = 0.032) during mid-phlebotomy. During recovery, the AMT group retained higher SV, higher CO and lower SVR than the control, but not reaching statistical significance. Practicing AMT during recovery resulted in sustained haemodynamic improvements beyond the donation period, despite the reduction in delayed VVR was insignificant compared to the control group. A larger sample size is needed to validate the effectiveness of performing AMT after donation to mitigate delayed VVR.
血管迷走性反应 (VVR) 会危及供者安全并降低其后续的返还率。在采血过程中进行主动肌肉收缩 (AMT) 可能会降低 VVR 的发生率。然而，在采血后进行 AMT 以减少迟发性 VVR 的效果尚不清楚。在获得伦理批准的情况下，招募了 12 名年轻的首次献血者 (YFTD) 来研究在从插入针头到恢复结束期间进行 AMT 对每搏量 (SV)、心输出量 (CO) 和全身血管阻力 (SVR) 的影响。使用 12 名匹配的对照 YFTD 的测量值进行比较。评估了献血前的焦虑和 VVR 严重程度。与对照组相比，进行 AMT 的供者 SV 更高（对照组：57 毫升对 AMT：69 毫升， = 0.045），CO 更高（对照组：3.7 升·分钟对 AMT：5.2 升·分钟， = 0.006），SVR 更低（对照组：1962 dyn·s·cm 对 AMT：1569 dyn·s·cm ， = 0.032）在 mid-phlebotomy 期间。在恢复期间，与对照组相比，AMT 组在恢复期间保留了更高的 SV、更高的 CO 和更低的 SVR，但未达到统计学意义。尽管与对照组相比，减少迟发性 VVR 并不显著，但在恢复期间进行 AMT 会导致持续的血液动力学改善。需要更大的样本量来验证在捐献后进行 AMT 以减轻迟发性 VVR 的有效性。
