苏氨酰 - tRNA合成酶基因在人类5号染色体上的定位靠近亮氨酰 - tRNA合成酶基因。

Threonyl-tRNA synthetase gene maps close to leucyl-tRNA synthetase gene on human chromosome 5.

作者信息

Gerken S C, Wasmuth J J, Arfin S M

出版信息

Somat Cell Mol Genet. 1986 Sep;12(5):519-22. doi: 10.1007/BF01539923.

Abstract

The structural gene for threonyl-tRNA synthetase was mapped to human chromosome 5 by an analysis of the isoelectric focusing patterns of this enzyme from human X Chinese hamster interspecific somatic cell hybrids. The threonyl-tRNA synthetase gene is the fourth of seven aminoacyl-tRNA synthetase genes mapped in humans to be assigned to this chromosome. Regional mapping studies showed that the threonyl-tRNA synthetase gene is on the short arm of chromosome 5, p13-cen, and is close to, but separable from, the gene for leucyl-tRNA synthetase which maps to 5cen-5q11.

摘要

通过对人 X 中国仓鼠种间体细胞杂种中该酶的等电聚焦图谱进行分析，将苏氨酰 - tRNA 合成酶的结构基因定位到人类 5 号染色体上。苏氨酰 - tRNA 合成酶基因是人类已定位到该染色体上的七个氨酰 - tRNA 合成酶基因中的第四个。区域定位研究表明，苏氨酰 - tRNA 合成酶基因位于 5 号染色体短臂 p13 - 着丝粒区域，且与定位在 5 号染色体着丝粒 - 5q11 的亮氨酰 - tRNA 合成酶基因相邻但可分离。