Wasmuth J J, Carlock L R
Somat Cell Mol Genet. 1986 Sep;12(5):513-7. doi: 10.1007/BF01539922.
The gene encoding histidyl-tRNA synthetase was localized to human chromosome 5 using human-Chinese hamster ovary cell hybrids. Seven of the functionally related genes encoding the 20 different aminoacyl-tRNA synthetases have not been mapped in humans and four are located on a single chromosome, number 5, which represents less than 7% of the total genome. Thus, there appears to be significant clustering of this group of genes which may reflect their evolutionary relatedness or common factors involved in regulating their expression.
利用人-中国仓鼠卵巢细胞杂种，将编码组氨酰-tRNA合成酶的基因定位到人类5号染色体上。编码20种不同氨酰-tRNA合成酶的7个功能相关基因尚未在人类中定位，4个位于单一染色体5号染色体上，该染色体占基因组总数不到7%。因此，这组基因似乎存在显著的聚类现象，这可能反映了它们的进化相关性或参与调节其表达的共同因素。
