Yunus M B, Kalyan-Raman U P, Kalyan-Raman K, Masi A T
Am J Med. 1986 Sep 29;81(3A):38-42. doi: 10.1016/0002-9343(86)90872-7.
Primary fibromyalgia syndrome, also inappropriately called "fibrositis," is a clinically recognizable nonarticular rheumatic condition with diffuse and chronic musculoskeletal aching and stiffness, accompanied by exaggerated tenderness at characteristic sites on physical examination. Results of muscle biopsy from 12 well-defined cases of primary fibromyalgia syndrome without any history of trauma have been published recently. Light microscopic examination revealed no evidence of inflammation. Histochemical analysis demonstrated type II fiber atrophy in seven patients and the "moth-eaten" appearance of type I fibers in five patients. Electron microscopic findings were most impressive, and included myofibrillar lysis with deposition of glycogen and abnormal mitochondria, as well as subsarcolemmal accumulation of glycogen and mitochondria in all 12 patients and papillary projections of sarcolemmal membrane in 11 patients. Mechanisms of these significant muscle changes in primary fibromyalgia syndrome are uncertain but may include subclinical injury of muscle spasm.
原发性纤维肌痛综合征，也被不恰当地称为“纤维织炎”，是一种临床上可识别的非关节性风湿性疾病，伴有弥漫性和慢性肌肉骨骼疼痛及僵硬，体格检查时在特征性部位有压痛加剧。最近公布了12例明确诊断为原发性纤维肌痛综合征且无任何创伤史患者的肌肉活检结果。光学显微镜检查未发现炎症迹象。组织化学分析显示，7例患者存在II型纤维萎缩，5例患者存在I型纤维的“虫蚀状”外观。电子显微镜检查结果最为显著，包括所有12例患者均有肌原纤维溶解伴糖原和线粒体沉积，以及糖原和线粒体在肌膜下积聚，11例患者有肌膜乳头样突起。原发性纤维肌痛综合征中这些显著肌肉变化的机制尚不确定，但可能包括肌肉痉挛的亚临床损伤。
