Kalyan-Raman U P, Kalyan-Raman K, Yunus M B, Masi A T
J Rheumatol. 1984 Dec;11(6):808-13.
Upper medial trapezius muscle biopsy was obtained from 12 primary fibromyalgia syndrome (PFS) patients (age 17 to 40 years) and studied with histochemistry, light and electron microscopy (EM). No evidence of inflammation was found in any case. Significant histochemical abnormalities were Type II fiber atrophy in 7 and moth-eaten appearance of Type I fibers in 5. EM revealed segmental muscle fiber necrosis with lipid and glycogen deposition as well as subsarcolemmal mitochondrial accumulation in all cases. Papillary projections of sarcolemmal membrane were seen in 11 patients. These observations in 12 PFS cases without obvious muscle trauma indicate definite but nonspecific muscle changes which we suspect are secondary to chronic muscle spasm and ischemia of unknown etiology.
从12例原发性纤维肌痛综合征（PFS）患者（年龄17至40岁）获取上内侧斜方肌活检组织，并进行组织化学、光镜和电镜（EM）研究。所有病例均未发现炎症迹象。显著的组织化学异常表现为7例出现II型纤维萎缩，5例出现I型纤维虫蚀样外观。电镜显示所有病例均有节段性肌纤维坏死，伴有脂质和糖原沉积以及肌膜下线粒体聚集。11例患者可见肌膜的乳头状突起。这12例无明显肌肉创伤的PFS病例的观察结果表明存在明确但非特异性的肌肉改变，我们怀疑这是继发于病因不明的慢性肌肉痉挛和缺血。
