Yunus M B, Kalyan-Raman U P
Department of Medicine, University of Illinois College of Medicine, Peoria.
Rheum Dis Clin North Am. 1989 Feb;15(1):115-34.
Virtually all the reports on muscle biopsy in chronic muscle pain conditions, except those of primary fibromyalgia syndrome (PFS) published recently, have inadequate methodologic information, particularly on definition of cases, and lack controlled materials, so that no firm conclusions may be made. A limited number of controlled studies of muscle biopsy in PFS suggest that results are negative by usual light microscopic, histochemical, and electron microscope examinations. The findings of abnormal rubber band-like structures and interconnecting network of reticular or elastic fibers in muscle fibers of certain PFS patients in a single study need to be confirmed by other centers by careful controlled and blinded observations. The findings that high-energy phosphate levels in tender PFS muscles are significantly reduced appear valid and important, and need to be independently confirmed by well-designed controlled and blinded studies. Finally, biopsy reports of unspecified or unclarified muscle pain syndromes should not be assumed to be those related to PFS, and such invalid references must be avoided.
几乎所有关于慢性肌肉疼痛病症肌肉活检的报告，除了近期发表的原发性纤维肌痛综合征（PFS）的报告外，都缺乏足够的方法学信息，尤其是关于病例定义方面，并且缺少对照材料，因此无法得出确凿结论。对PFS进行的有限数量的肌肉活检对照研究表明，通过常规光学显微镜、组织化学和电子显微镜检查，结果均为阴性。在一项研究中，某些PFS患者肌肉纤维中出现异常橡皮筋样结构以及网状或弹性纤维相互连接网络的发现，需要其他中心通过仔细的对照和盲法观察来证实。PFS压痛肌肉中高能磷酸水平显著降低这一发现似乎是有效的且重要的，需要通过精心设计的对照和盲法研究进行独立验证。最后，不应将未明确或未阐明的肌肉疼痛综合征的活检报告假定为与PFS相关的报告，必须避免此类无效参考。
