Y2Y Technology, Santa Clara, CA, 95052, USA.
Particle Technology Lab, Mechanical Engineering Department, Minneapolis, MN, 55455, USA.
Sci Rep. 2021 Oct 12;11(1):20268. doi: 10.1038/s41598-021-99768-x.
Intentionally intensifying the light scattering of medium molecules can allow the detection of suspended nanoparticles under conditions not suitable for conventional optical microscopies or laser particle counters. Here, we demonstrate how the collective light scattering of medium molecules and nanoparticles is imaged in response to the power, frequency, and oscillating direction of the incident light wave electric field, and how this response can be used to distinguish between nanoparticles and microparticles, such as viruses or bacteria. Under conditions that the medium light scattering is intensified, suspended nanoparticles appear as magnified shiny moving dots superimposed on the quasi-steady background of medium light scattering. Utilizing the visual enlargement resulted from the enhanced light scattering and possible light interference, we can detect directly suspended nanoparticles that are much smaller than visible light wavelengths even in unopened water bottles or other large containers. This suggests new approaches for detecting nanoparticles with many potential applications.
有意增强介质分子的光散射,可以在不适合传统光学显微镜或激光粒子计数器的条件下检测悬浮的纳米粒子。在这里,我们展示了如何根据入射光波电场的功率、频率和振荡方向来对介质分子和纳米粒子的集体光散射进行成像,以及如何利用这种响应来区分纳米粒子和微米粒子,如病毒或细菌。在增强介质光散射的条件下,悬浮的纳米粒子呈现出放大的闪亮移动点,叠加在介质光散射的准稳态背景上。利用增强光散射和可能的光干涉产生的视觉放大效果,我们可以直接检测到悬浮的纳米粒子,即使在未开封的水瓶或其他大容器中,这些纳米粒子也比可见光波长小得多。这为检测具有许多潜在应用的纳米粒子提供了新的方法。