Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
EMBO J. 2021 Nov 15;40(22):e109683. doi: 10.15252/embj.2021109683. Epub 2021 Oct 12.
While canonical and non-canonical functions of pyruvate kinase M2 (PKM2) are recognized to mediate often-opposing roles in cancer, its contribution to cellular and systemic fatty acid homeostasis remains poorly understood. A new study by Liu et al (2021) uncovers ER transmembrane protein TMEM33 as a novel target of PKM2, which is essential for regulation of cancer cell cholesterol metabolism. These findings highlight the diversity of tissue-specific functions of PKM2 and potential implications for cancer treatment.
虽然丙酮酸激酶 M2（PKM2）的经典和非经典功能已被认为在癌症中发挥着经常相互对立的作用，但它对细胞和全身脂肪酸动态平衡的贡献仍知之甚少。刘等人的一项新研究揭示了内质网跨膜蛋白 TMEM33 是 PKM2 的一个新靶标，对于调节癌细胞胆固醇代谢至关重要。这些发现强调了 PKM2 的组织特异性功能的多样性及其对癌症治疗的潜在影响。
