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World Prematurity Day: it takes an NIH village to prevent preterm birth and improve treatments for preterm infants.世界早产日：需要 NIH 全村的力量来预防早产并改善早产儿的治疗。
Am J Physiol Lung Cell Mol Physiol. 2021 Nov 1;321(5):L960-L969. doi: 10.1152/ajplung.00401.2021. Epub 2021 Oct 13.
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本文引用的文献

1
SARS-CoV-2 and the subsequent development of preeclampsia and preterm birth: evidence of a dose-response relationship supporting causality.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）与子痫前期和早产的后续发展：支持因果关系的剂量反应关系证据。
Am J Obstet Gynecol. 2021 Dec;225(6):689-693.e1. doi: 10.1016/j.ajog.2021.08.020. Epub 2021 Aug 26.
2
A standardized definition of placental infection by SARS-CoV-2, a consensus statement from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development SARS-CoV-2 Placental Infection Workshop.SARS-CoV-2 胎盘感染的标准化定义：美国国立卫生研究院/肯尼迪·施莱佛国立儿童健康与人类发育研究所 SARS-CoV-2 胎盘感染研讨会的共识声明。
Am J Obstet Gynecol. 2021 Dec;225(6):593.e1-593.e9. doi: 10.1016/j.ajog.2021.07.029. Epub 2021 Aug 5.
3
A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection.巨细胞病毒免疫球蛋白预防先天性巨细胞病毒感染的临床试验
N Engl J Med. 2021 Jul 29;385(5):436-444. doi: 10.1056/NEJMoa1913569.
4
Higher dose docosahexaenoic acid supplementation during pregnancy and early preterm birth: A randomised, double-blind, adaptive-design superiority trial.孕期及早产早期补充高剂量二十二碳六烯酸：一项随机、双盲、适应性设计的优效性试验。
EClinicalMedicine. 2021 May 17;36:100905. doi: 10.1016/j.eclinm.2021.100905. eCollection 2021 Jun.
5
SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis.孕期感染严重急性呼吸综合征冠状病毒2与子痫前期风险：一项系统评价和荟萃分析。
Am J Obstet Gynecol. 2022 Jan;226(1):68-89.e3. doi: 10.1016/j.ajog.2021.07.009. Epub 2021 Jul 21.
6
Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth.基于人群的孕妇血液多组学评估预测孕龄和早产。
Cell Rep Med. 2021 Jun 15;2(6):100323. doi: 10.1016/j.xcrm.2021.100323.
7
The amniotic fluid cell-free transcriptome in spontaneous preterm labor.自发性早产孕妇羊水中的无细胞转录组。
Sci Rep. 2021 Jun 29;11(1):13481. doi: 10.1038/s41598-021-92439-x.
8
Prenatal Exposure to Glyphosate and Its Environmental Degradate, Aminomethylphosphonic Acid (AMPA), and Preterm Birth: A Nested Case-Control Study in the PROTECT Cohort (Puerto Rico).孕期暴露于草甘膦及其环境降解产物氨甲基膦酸（AMPA）与早产的关系：波多黎各 PROTECT 队列的巢式病例对照研究。
Environ Health Perspect. 2021 May;129(5):57011. doi: 10.1289/EHP7295. Epub 2021 May 19.
9
Progesterone receptor isoform B regulates the -- pathway to suppress uterine contractility.孕激素受体 B 异构体通过调节 -- 途径来抑制子宫收缩。
Proc Natl Acad Sci U S A. 2021 Mar 16;118(11). doi: 10.1073/pnas.2011643118.
10
Resolution of acute cervical insufficiency after antibiotics in a case with amniotic fluid sludge.羊水胎粪污染病例应用抗生素后急性宫颈功能不全的缓解
J Matern Fetal Neonatal Med. 2022 Dec;35(25):5416-5426. doi: 10.1080/14767058.2021.1881477. Epub 2021 Feb 17.

世界早产日：需要 NIH 全村的力量来预防早产并改善早产儿的治疗。

World Prematurity Day: it takes an NIH village to prevent preterm birth and improve treatments for preterm infants.

机构信息

Division of Extramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.

Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.

出版信息

Am J Physiol Lung Cell Mol Physiol. 2021 Nov 1;321(5):L960-L969. doi: 10.1152/ajplung.00401.2021. Epub 2021 Oct 13.

DOI:10.1152/ajplung.00401.2021
PMID:34643102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8616612/
Abstract

Prematurity remains a major cause of morbidity and mortality. Research to prevent preterm birth and improve treatments for preterm infants involves both intramural and extramural research, not just at the National Institute of Child Health and Human Development, but across many institutes and centers at the National Institutes of Health.

摘要

早产仍是发病和死亡的主要原因。预防早产和改善早产儿治疗的研究不仅涉及国立儿童健康与人类发展研究所内的研究，也涉及国立卫生研究院(National Institutes of Health)的许多研究所和中心的所内外研究。