Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation, Huazhong University of Science and Technology, Wuhan, 430030, China.
Adv Mater. 2022 Feb;34(6):e2106701. doi: 10.1002/adma.202106701. Epub 2021 Dec 22.
Smart attachable systems have attracted much attention owing to their capabilities in terms of body performance evaluation, disease diagnostics, and drug delivery. Recent advances in chemical and engineering techniques provide many opportunities to improve device fabrication and applications owing to the advantages of being lightweight and easy to control as well as their battery absence and functional diversity. This review highlights the latest developments in the field of chemical engineering-based lightweight and miniaturized attachable systems, which are mainly inspired by the natural world. Their applications for real-time monitoring, point-of-care sampling, biomarker detection, and controlled release are discussed thoroughly with respect to specific products/prototypes. The perspectives of the field, including persistence guarantee, burden reduction, and personality improvement, are also discussed. It is believed that chemical engineering-based lightweight and miniaturized attachable systems have good potential in both clinical and industrial fields, indicating a large potential to improve human lives in the near future.
智能附着系统因其在人体性能评估、疾病诊断和药物输送方面的能力而受到广泛关注。化学和工程技术的最新进展为改善设备制造和应用提供了许多机会，因为它们具有重量轻、易于控制、无需电池和功能多样化的优点。本综述重点介绍了基于化学工程的轻质和微型附着系统领域的最新进展，这些系统主要受到自然界的启发。详细讨论了它们在实时监测、即时采样、生物标志物检测和控制释放方面的应用，以及针对特定产品/原型的应用。还讨论了该领域的观点，包括持久性保证、负担减轻和个性提升。相信基于化学工程的轻质和微型附着系统在临床和工业领域具有很好的潜力，这表明在不久的将来有很大的潜力改善人类的生活。
