急性髓细胞白血病（M2）病例中的新型易位（1；8；21）

New variant translocation (1;8;21) in a case of acute myeloblastic leukemia (M2).

作者信息

Taguchi H, Kitagawa T, Yamashita M, Kubonishi I, Miyoshi I

出版信息

Cancer Genet Cytogenet. 1986 Nov;23(3):219-23. doi: 10.1016/0165-4608(86)90181-0.

Abstract

A new translocation involving chromosome #1, #8, and #21 in a patient with type M2 acute myeloblastic leukemia is reported. The breakpoint of #1 in this case was at band p13 and differed from that in two previously reported cases of t(1;8;21) involving the long arm of #1. A key event leading to the development of the M2 phenotype appears to be a break at band q22 of #8 with associated translocation of the terminal end of the long arm of #21.

摘要

报告了一名M2型急性髓细胞白血病患者中涉及1号、8号和21号染色体的一种新易位。该病例中1号染色体的断点位于p13带，与之前报道的两例涉及1号染色体长臂的t(1;8;21)病例不同。导致M2表型发展的关键事件似乎是8号染色体q22带的断裂以及21号染色体长臂末端的相关易位。