糖原贮积病Ib型中单核细胞功能受损。

Impaired monocyte function in glycogen storage disease type Ib.

作者信息

Ueno N, Tomita M, Ariga T, Ohkawa M, Nagano S, Takahashi Y, Arashima S, Matsumoto S

出版信息

Eur J Pediatr. 1986 Sep;145(4):312-4. doi: 10.1007/BF00439409.

Abstract

Phagocyte (neutrophil and monocyte) function was evaluated in a boy with glycogen storage disease type Ib. Neutrophils were found to be defective in motility and respiratory burst and monocytes showed a defect in respiratory burst but not in motility. These results suggested that the glucose-6-phosphate transport system plays a role in the function of neutrophils and monocytes and that these two phagocytes are different from each other in their energy metabolism for motility.

摘要

对一名患有Ⅰb型糖原贮积病的男孩的吞噬细胞（中性粒细胞和单核细胞）功能进行了评估。发现中性粒细胞在运动性和呼吸爆发方面存在缺陷，而单核细胞在呼吸爆发方面存在缺陷，但在运动性方面没有缺陷。这些结果表明，6-磷酸葡萄糖转运系统在中性粒细胞和单核细胞的功能中发挥作用，并且这两种吞噬细胞在运动的能量代谢方面彼此不同。