Laboratorio de Farmacia, Facultad de Ciencias Químicas, Universidad de Colima, Coquimatlán, Colima, México.
Laboratorio de Cromatografía, Facultad de Química, Universidad Autónoma de Yucatán, Colonia Inalámbrica, Mérida, Yucatán, México.
J Pharm Pharm Sci. 2021;24:509-532. doi: 10.18433/jpps31788.
Nanoparticles have shown overall beneficial effects in drug administration. Specifically, solid lipid nanoparticles (SLN) have emerged as an alternative to polymer-based systems. However, the oral administration of SLN, the first choice for conventional medications, has not been addressed due to the taboo surrounding the complicated transit that this delivery route entails. This review focuses on the encapsulation of drugs into SLN as a strategy for improving oral administration. Examples of applications of SLN to enhance the absorption and bioavailability of poorly-soluble drugs and protect acid-labile active molecules are discussed. This work also emphasizes the importance of developing SLN-based systems to treat health issues such as neurological diseases and cancer, and combat antibiotic resistance, three significant and increasingly common current public health problems. The review sections clarify how SLN can improve bioavailability, target therapeutic agents, and reduce side effects.
纳米粒子在药物给药方面显示出整体的有益效果。具体而言，固体脂质纳米粒（SLN）已经成为聚合物基系统的替代品。然而，由于口服给予 SLN 这种给药途径所涉及的复杂转运存在禁忌，因此尚未解决常规药物首选的口服给予途径。本综述重点介绍了将药物包封到 SLN 中作为改善口服给药的策略。讨论了将 SLN 应用于提高难溶性药物的吸收和生物利用度以及保护酸不稳定活性分子的例子。这项工作还强调了开发基于 SLN 的系统来治疗神经疾病和癌症等健康问题以及对抗抗生素耐药性的重要性，这是当前三个重大且日益普遍的公共卫生问题。综述部分阐明了 SLN 如何提高生物利用度、靶向治疗剂和减少副作用。
