Beyond Chemistry: Investigating the Physical, Pharmacological, and Computational Aspects of Polyoxometalate Integrated Solid Lipid Nanoparticles for Cancer Treatment.

PURPOSE

The solid lipid nanoparticles of transitional metal complexes (POMs) were prepared with natural lipids with the aim of developing a safer therapeutic approach for cancer treatment.

METHODS

Natural lipids were used to create solid lipid nanoparticles containing transitional metal complexes (POMs).

RESULTS

The nanoparticles had displayed appreciable entrapment and loading percentage of PW. The zeta capacitance was measured to be -32.57±6.44 mV with average particle dimension of 160.5±8.61 nm and polydispersity index (PDI) of around 0.3814±0.096. The effectiveness of PW-BW-SLNs in inhibiting the growth of HeLa cells was found to be higher (IC = 3.02±2.14 µg/mL) compared to pure PW (IC = 7.93±5.08 µg/mL). Further examinations of DNA damage were made through comet test and flow cytometry techniques. The assessment of tumor regression and survival was conducted, and comparison was recorded. The PW-BW-SLNs resulted in a 72.91% increase in survival rates and a reduction in tumor burden by 2.967±0.543%. Moreover, the computational findings demonstrate a strong connection with the actual data, providing a plausible explanation for the notable chemopreventive efficacy of POM against HeLa cell lines.

CONCLUSION

The study's findings might pave the way for a more efficient delivery system in cancer treatment.