Jia Yaoxia, Li Xing, Meng Xiangqi, Lei Jinjie, Xia Yangmiao, Yu Lingying
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, No. 1166 Liutai Avenue, Chengdu, 611137, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.
Chin Med. 2023 Oct 24;18(1):138. doi: 10.1186/s13020-023-00839-0.
Cancer is a malignant disease that has plagued human beings all the time, but the treatment effect of commonly used anticancer drugs in clinical practice is not ideal by reason of their drug tolerance and Strong adverse reactions to patients. Therefore, it is imperative to find effective and low-toxic anticancer drugs. Many research works have shown that natural products in Chinese herbal medicine have great anticancer potential, such as 6-shogaol, a monomer composition obtained from Chinese herbal ginger, which has been confirmed by numerous in vitro or vivo studies to be an excellent anti-cancer active substance. In addition, most notably, 6-shogaol has different selectivity for normal and cancer cells during treatment, which makes it valuable for further research and clinical development. Therefore, this review focus on the anti-cancer attributes, the mechanism and the regulation of related signaling pathways of 6-shogaol. In addition, its synergy with commonly used anticancer drugs, potential drug delivery systems and prospects for future research are discussed. This is the first review to comprehensively summarize the anti-cancer mechanism of 6-shogaol, hoping to provide a theoretical basis and guiding significance for future anti-cancer research and clinical development of 6-shogaol.
癌症是一种一直困扰着人类的恶性疾病，但临床实践中常用抗癌药物的治疗效果因药物耐受性和对患者的强烈不良反应而不理想。因此，寻找有效且低毒的抗癌药物势在必行。许多研究工作表明，中草药中的天然产物具有巨大的抗癌潜力，例如从姜这种中草药中获得的单体成分6-姜辣素，大量的体外或体内研究已证实其是一种出色的抗癌活性物质。此外，最值得注意的是，6-姜辣素在治疗过程中对正常细胞和癌细胞具有不同的选择性，这使其具有进一步研究和临床开发的价值。因此，本综述聚焦于6-姜辣素的抗癌特性、作用机制及相关信号通路的调控。此外，还讨论了其与常用抗癌药物的协同作用、潜在的药物递送系统以及未来的研究前景。这是首次全面总结6-姜辣素抗癌机制的综述，希望能为6-姜辣素未来的抗癌研究和临床开发提供理论依据和指导意义。
