Costa Jackeline Oliveira, Barral Thiago Doria, Portela Ricardo Dias, da Costa Laura Nicole Filipin, Bittencourt Catarina Nunes, Machado Alessandro Lima, Marques Franciane Santos, Cavalcante Ana Karina da Silva
Postgraduate Program in Animal Science in the Tropics, Federal University of Bahia, Salvador, Bahia State 40170-110, Brazil.
Laboratory of Immunology and Molecular Biology, Health Sciences Institute, Federal University of Bahia, Salvador, Bahia State 40110-100, Brazil.
Domest Anim Endocrinol. 2022 Jan;78:106677. doi: 10.1016/j.domaniend.2021.106677. Epub 2021 Sep 4.
Caseous Lymphadenitis (CLA) is an infectious disease that affects small ruminants, and the bacterium Corynebacterium pseudotuberculosis is its etiologic agent. This disease presents a high morbidity and a great economic impact on goat farming, leading to reduced milk and meat production and reproductive losses. The available data about the influence of C. pseudotuberculosis on the reproductive system were obtained after experimental inoculations. In this way, this study aimed to evaluate the influence of the natural infection by C. pseudotuberculosis on the luteal function and serum progesterone (P) levels in goats. Sixteen female goats were diagnosed for the presence of C. pseudotuberculosis specific antibodies and divided into 2 groups: CLA positive and negative animals. They were submitted to estrous synchronization, followed by controlled mating. Corpus luteum and serum levels of P were evaluated on the 7th and 20th days after mating (D7 and D20). The ultrasonographic results were not statistically different between the 2 groups, as well as serum P levels on D7. However, a significant increase in serum P levels on the CLA positive group was identified on D20, along with a significant correlation between C. pseudotuberculosis specific antibody production, and P serum levels. The result of this study indicates that the infection by C. pseudotuberculosis may influence the reproductive status of female goats through an enhanced production of progesterone.
干酪性淋巴结炎（CLA）是一种影响小型反刍动物的传染病，其病原体为伪结核棒状杆菌。这种疾病发病率高，对山羊养殖造成巨大经济影响，导致产奶量和产肉量下降以及繁殖损失。关于伪结核棒状杆菌对生殖系统影响的现有数据是通过实验接种获得的。因此，本研究旨在评估伪结核棒状杆菌自然感染对山羊黄体功能和血清孕酮（P）水平的影响。16只雌性山羊被诊断出存在伪结核棒状杆菌特异性抗体，并分为两组：CLA阳性和阴性动物。它们接受了发情同步处理，随后进行了人工授精。在配种后第7天和第20天（D7和D20）评估黄体和血清P水平。两组之间的超声检查结果以及D7时的血清P水平在统计学上没有差异。然而，在D20时，CLA阳性组的血清P水平显著升高，同时伪结核棒状杆菌特异性抗体产生与血清P水平之间存在显著相关性。本研究结果表明，伪结核棒状杆菌感染可能通过增加孕酮的产生来影响雌性山羊的生殖状态。
