Dermatology Unit, Department of Small Animal Medicine and Surgery, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK.
Present address: Dermatology Referral Service, 7 Chadwell, Ware, Herts, UK.
Vet Dermatol. 2000 Mar;11(1):35-41. doi: 10.1046/j.1365-3164.2000.00168.x.
The clinical and histopathological features of 13 Persian cats which presented with chronic skin disease primarily affecting the face are described. Lesions were characterized by black material adherent to the skin and hair, accompanied by erythema and variable degrees of excoriation. Concurrent ceruminous otitis externa was observed in 7 cases. Histopathological examination of skin biopsy specimens showed marked acanthosis with crusting, hydropic degeneration and dyskeratotic basal epithelial cells, a mixed diffuse superficial inflammatory infiltrate and sebaceous hyperplasia. Malassezia pachydermatis yeasts and various bacteria were isolated from the lesions in some of the cats but in no case was antimicrobial therapy curative. The response to glucocorticoids was variable and often poor. No satisfactory therapeutic regimen could be identified and the cause of the disorder is unknown although a genetic basis is possible.
描述了13只主要面部出现慢性皮肤病的波斯猫的临床和组织病理学特征。病变的特点是皮肤和毛发上附着黑色物质，伴有红斑和不同程度的擦伤。7只猫同时观察到外耳道炎。皮肤活检标本的组织病理学检查显示明显的棘皮症，伴有结痂、水肿变性和角化不良的基底上皮细胞，混合性弥漫性浅表炎症浸润和皮脂腺增生。在一些猫的病变中分离出厚皮马拉色霉菌和各种细菌，但抗菌治疗无一例治愈。对糖皮质激素的反应各不相同，且往往不佳。尽管可能存在遗传基础，但未能确定令人满意的治疗方案，病因不明。
