Outerbridge Catherine A, Affolter Verena K, Lyons Leslie A, Crothers Samantha L, Lam Andrea T H, Bonenberger Terri E, Ihrke Peter J, White Stephen D
Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA, 95616, USA.
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA, 95616, USA.
Vet Dermatol. 2018 Feb;29(1):81-e33. doi: 10.1111/vde.12501. Epub 2017 Oct 6.
Between 2000 and 2012, nine cats were examined with a visually distinctive, progressive crusting dermatitis that was poorly responsive to all attempted therapies.
Documentation of clinical and histopathological findings of this disease.
Nine privately owned cats.
Retrospective study.
Eight neutered males and one (presumably spayed) female ranging in age from two to eight years, presented for a progressive, well-demarcated, crusting dermatitis with variable pruritus of 1.5 months to five years duration. All cats lived in northern California, USA; seven lived within a 30 mile radius. Two males were littermates. Histopathological investigation showed both parakeratotic and orthokeratotic crusts, intraepidermal pustules and superficial folliculitis with rare to frequent acantholytic cells. Bacterial and fungal cultures were performed in six cats: meticillin-susceptible Staphylococcus pseudintermedius was isolated in three cats, two colonies of Trichophyton terrestre and three of Malassezia pachydermatis were isolated from one cat each. Treatment with various antibiotics, antifungal and a variety of immunosuppressive medications did not alter the progressive nature of the skin disease.
The described disease shares some clinical and histopathological features with pemphigus foliaceus, but the lack of response to treatment, its progressive nature and the possible relatedness of some of the cats set it apart. The aetiology of this acantholytic dermatitis remains unknown.
2000年至2012年间，对9只猫进行了检查，这些猫患有一种视觉上有明显特征的进行性结痂性皮炎，对所有尝试的治疗反应不佳。
记录这种疾病的临床和组织病理学发现。
9只私人饲养的猫。
回顾性研究。
8只去势雄性猫和1只（推测已绝育）雌性猫，年龄在2至8岁之间，出现进行性、界限清楚的结痂性皮炎，伴有程度不一的瘙痒，病程为1.5个月至5年。所有猫都生活在美国加利福尼亚州北部；7只生活在半径30英里的范围内。2只雄性猫是同窝出生的。组织病理学检查显示有角化不全和角化过度的痂皮、表皮内脓疱以及浅表毛囊炎，棘层松解细胞少见至常见。对6只猫进行了细菌和真菌培养：3只猫分离出对甲氧西林敏感的中间型葡萄球菌，1只猫分离出2个 terrestre 毛癣菌菌落和3个厚皮马拉色菌菌落。使用各种抗生素、抗真菌药和多种免疫抑制药物治疗均未改变皮肤病的进行性特征。
所描述的疾病与落叶型天疱疮有一些临床和组织病理学特征，但对治疗无反应、其进行性本质以及部分猫之间可能的关联性使其有所不同。这种棘层松解性皮炎的病因仍然未知。
