Vaxine Pty Ltd, 11 Walkley Avenue, Adelaide, 5046, Australia.
College of Medicine & Public Health, Flinders University, Adelaide, 5042, Australia.
Bioanalysis. 2021 Dec;13(24):1805-1826. doi: 10.4155/bio-2021-0096. Epub 2021 Oct 14.
Vaccines are key in charting a path out of the COVID-19 pandemic. However, development of new vaccines is highly dependent on availability of analytical methods for their design and evaluation. This paper highlights the challenges presented in having to rapidly develop vaccine analytical tools during an ongoing pandemic, including the need to address progressive virus mutation and adaptation which can render initial assays unreliable or redundant. It also discusses the potential of new computational modeling techniques to model and analyze key viral proteins and their attributes to assist vaccine production and assay design. It then reviews the current range of analytical tools available for COVID-19 vaccine application, ranging from assays for immunogen characterization to assays to measure vaccine responses . Finally, it provides a future perspective for COVID-19 vaccine analytical tools and attempts to predict how the field might evolve over the next 5-10 years.
疫苗是走出 COVID-19 大流行的关键。然而，新疫苗的开发高度依赖于用于设计和评估的分析方法的可用性。本文强调了在持续大流行期间必须快速开发疫苗分析工具所面临的挑战，包括需要解决病毒不断突变和适应的问题，这可能导致初始检测变得不可靠或多余。它还讨论了新的计算建模技术在建模和分析关键病毒蛋白及其特性以协助疫苗生产和检测设计方面的潜力。然后，它回顾了当前可用于 COVID-19 疫苗应用的各种分析工具，范围从免疫原特性检测到疫苗反应检测。最后，它对 COVID-19 疫苗分析工具的未来进行了展望，并尝试预测该领域在未来 5-10 年内可能的发展方向。
