Dubrova Iu E, Ikramov K M, Altukhov Iu P
Genetika. 1986 Aug;22(8):2202-7.
Distribution of individual heterozygosity (the number of heterozygous loci per individual), wife/husband genetical differences and frequencies of genotypes formed by paired combination of eight polymorphic loci were studied in a group of couples and single women with repeated spontaneous abortions, and in a group of couples with normal fertility. No statistically significant differences were found for the first two parameters. Marked increase of genetical variability was shown for the women with repeated spontaneous abortions, as consequence of elevation of frequency of rare genotypic paired combinations. Therefore, differential fertility, as a component of stabilizing selection, alters the distribution of complex genotypes in human populations.
在一组有反复自然流产史的夫妇和单身女性以及一组生育能力正常的夫妇中，研究了个体杂合性（每个个体的杂合位点数量）的分布、夫妻间的遗传差异以及由八个多态性位点的配对组合形成的基因型频率。前两个参数未发现统计学上的显著差异。有反复自然流产史的女性显示出遗传变异性显著增加，这是罕见基因型配对组合频率升高的结果。因此，作为稳定选择的一个组成部分，生育差异改变了人类群体中复杂基因型的分布。
