[人类生育力差异的群体遗传学研究（以习惯性流产为例）。II. 多种生化标记的基因型分布及杂合性水平]

[Population genetics study of differential fertility in humans (based on an example of habitual abortion). II. Distribution of genotypes and heterozygosity levels for a variety of biochemical markers].

作者信息

Ikramov K M, Dubrova Iu E, Altukhov Iu P, Podogas A V

出版信息

Genetika. 1986 Aug;22(8):2192-201.

Abstract

Hereditary variation of 21 blood proteins coded by 22 monomorphic and 9 polymorphic loci was compared in 171 couples and 120 women with repeated spontaneous abortions in anamnesis (experimental group) and 183 couples with normal fertility (control group). Significant elevation of frequency of rare protein electrophoretic variants, marked deviation in distribution of genotypes for polymorphic loci, alteration in observed heterozygosity level were not found in experimental group. Statistically significant decrease in average value of D index (D = (hobs-hexp)/hexp; hobs, hexp--observed and expected heterozygosity per locus) was found in women of experimental group.

摘要

对171对夫妇以及120名有反复自然流产病史的女性（实验组）和183对生育能力正常的夫妇（对照组），比较了由22个单态位点和9个多态位点编码的21种血液蛋白的遗传变异。在实验组中未发现稀有蛋白电泳变体频率显著升高、多态位点基因型分布明显偏差以及观察到的杂合度水平改变。在实验组女性中发现D指数（D = (hobs - hexp)/hexp；hobs、hexp分别为每个位点观察到的和预期的杂合度）的平均值有统计学意义的下降。

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