Jacobelli S, Arteaga A, Bidegain F
J Rheumatol. 1986 Aug;13(4):774-7.
The relationship between gout and coronary disease is controversial. We studied the distribution of cholesterol among lipoprotein fractions separated by ultracentrifugation in a group of 29 gouty men and 34 healthy controls, matched by age, weight and serum glucose. Our results showed that patients had significantly higher serum triglycerides and cholesterol-VLDL and lower total cholesterol and cholesterol in LDL and HDL fractions. The comparison of both groups separated by weight and alcohol intake showed similar results. The cholesterol-LDL/cholesterol-HDL ratio was not significantly different between the groups. Based on these results, we conclude that our group of gouty patients may not be at greater risk of coronary disease than a similar control population.
痛风与冠状动脉疾病之间的关系存在争议。我们对29名痛风男性患者和34名年龄、体重及血糖相匹配的健康对照者进行了研究，通过超速离心法分离脂蛋白组分，分析胆固醇在其中的分布情况。结果显示，患者的血清甘油三酯、胆固醇 - 极低密度脂蛋白显著升高，而总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇降低。按体重和酒精摄入量对两组进行比较，结果相似。两组之间胆固醇 - 低密度脂蛋白/胆固醇 - 高密度脂蛋白比值无显著差异。基于这些结果，我们得出结论，与相似的对照人群相比，我们研究的痛风患者群体患冠状动脉疾病的风险可能并不更高。
