The Key Laboratory of Molecular Biology, Hainan Medical University, Haikou, China.
Haikou Customs, District P. R. China, Haikou, P. R. China.
PLoS One. 2021 Oct 14;16(10):e0258489. doi: 10.1371/journal.pone.0258489. eCollection 2021.
Betel nut chewing (BNC) is prevalent in South Asia and Southeast Asia. BNC can affect host health by modulating the gut microbiota. The aim of this study is to evaluate the effect of BNC on the gut microbiota of the host. Feces samples were obtained from 34 BNC individuals from Ledong and Lingshui, Hainan, China. The microbiota was analyzed by 16S rRNA gene sequencing. BNC decreased the microbial α-diversity. Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria were the predominant phyla, accounting for 99.35% of the BNC group. The Firmicutes-to-Bacteroidetes ratio was significantly increased in the BNC group compared to a control group. The abundances of the families Aerococcaceae, Neisseriaceae, Moraxellaceae, Porphyromonadaceae, and Planococcaceae were decreased in the BNC/BNC_Male/BNC_Female groups compared to the control group, whereas the abundances of Coriobacteriaceae, Streptococcaceae, Micrococcaceae, Xanthomonadaceae, Coxiellaceae, Nocardioidaceae, Rhodobacteraceae, and Succinivibrionaceae were increased. In general, the gut microbiome profiles suggest that BNC may have positive effects, such as an increase in the abundance of beneficial microbes and a reduction in the abundance of disease-related microbes. However, BNC may also produce an increase in the abundance of disease-related microbes. Therefore, extraction of prebiotic components could increase the beneficial value of betel nut.
咀嚼槟榔（BNC）在南亚和东南亚地区很普遍。BNC 可以通过调节肠道微生物群来影响宿主健康。本研究旨在评估 BNC 对宿主肠道微生物群的影响。从中国海南乐东和陵水的 34 名 BNC 个体中获得粪便样本。通过 16S rRNA 基因测序分析微生物群。BNC 降低了微生物的 α 多样性。厚壁菌门、拟杆菌门、放线菌门和变形菌门是主要的门，占 BNC 组的 99.35%。与对照组相比，BNC 组的厚壁菌门/拟杆菌门比值显著增加。与对照组相比，BNC/BNC_男性/BNC_女性组中的 Aerococcaceae、Neisseriaceae、Moraxellaceae、Porphyromonadaceae 和 Planococcaceae 的丰度降低，而 Coriobacteriaceae、Streptococcaceae、Micrococcaceae、Xanthomonadaceae、Coxiellaceae、Nocardioidaceae、Rhodobacteraceae 和 Succinivibrionaceae 的丰度增加。总的来说，肠道微生物组谱表明，BNC 可能具有积极的影响，例如有益微生物丰度的增加和与疾病相关的微生物丰度的减少。然而，BNC 也可能产生与疾病相关的微生物丰度增加。因此，提取益生元成分可以增加槟榔的有益价值。
