McQueen E G, Facoory B, Faed J M
N Z Med J. 1986 May 28;99(802):358-60.
The effect of some newer non steroidal inflammatory drugs on platelet function has been assessed using platelet malondialdehyde production as a measure of cyclooxygenase activity. After single doses of the short acting NSAID's diflunisal, naproxen and sulindac, platelet malondialdehyde production was substantially diminished at one and three hours. It had largely recovered by 24 hours and had returned to normal by 48 hours. After aspirin malondialdehyde production was markedly reduced and was still down at 72 hours. After the long acting NSAID piroxicam, in doses providing blood levels comparable with those in long term treatment, malondialdehyde production was still down at 72 hours.
一些新型非甾体抗炎药对血小板功能的影响已通过测量血小板丙二醛生成量来评估环氧化酶活性。单次给予短效非甾体抗炎药双氯芬酸、萘普生和舒林酸后，在1小时和3小时时血小板丙二醛生成量显著减少。到24小时时已基本恢复，48小时时恢复正常。服用阿司匹林后，丙二醛生成量明显减少，72小时时仍较低。服用长效非甾体抗炎药吡罗昔康后，给予能使血药浓度与长期治疗相当的剂量，72小时时丙二醛生成量仍较低。
