Department of Neurology, Goethe University, Frankfurt am Main, Germany; Brain Imaging Center, Goethe University, Frankfurt am Main, Germany.
Department of Radiology, Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.
Neurobiol Aging. 2022 Jan;109:31-42. doi: 10.1016/j.neurobiolaging.2021.08.020. Epub 2021 Sep 6.
Recently, it was shown that patients with Parkinson's disease (PD) who exhibit an "Alzheimer's disease (AD)-like" pattern of brain atrophy are at greater risk for future cognitive decline. This study aimed to investigate whether this association is domain-specific and whether atrophy associated with brain aging also relates to cognitive impairment in PD. SPARE-AD, an MRI index capturing AD-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort. All patients underwent an extensive neuropsychological test battery. Patients diagnosed with mild cognitive impairment or dementia were found to have higher SPARE-AD scores as compared to patients with normal cognition and healthy controls. All patient groups showed increased brain age. SPARE-AD predicted impairment in memory, language and executive functions, whereas advanced brain age was associated with deficits in attention and working memory. Data suggest that SPARE-AD and brain age are differentially related to domain-specific cognitive decline in PD. The underlying pathomechanisms remain to be determined.
最近的研究表明，出现“阿尔茨海默病（AD）样”脑萎缩模式的帕金森病（PD）患者未来认知能力下降的风险更高。本研究旨在探讨这种关联是否具有特定领域的特征，以及与大脑衰老相关的萎缩是否也与 PD 患者的认知障碍有关。从 LANDSCAPE 队列中 178 名 PD 患者和 84 名健康对照的纵向结构影像学数据中计算了 SPARE-AD（一种捕获 AD 样萎缩的 MRI 指数）和基于萎缩的大脑年龄估计值。所有患者均接受了广泛的神经心理学测试。与认知正常的患者和健康对照组相比，被诊断为轻度认知障碍或痴呆的患者 SPARE-AD 评分更高。所有患者组的大脑年龄都增加了。SPARE-AD 预测记忆、语言和执行功能障碍，而高级大脑年龄与注意力和工作记忆缺陷相关。数据表明，SPARE-AD 和大脑年龄与 PD 患者特定领域的认知能力下降存在差异相关。潜在的发病机制仍有待确定。
