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五种用于电子和质子治疗束的凝胶剂量计配方的线性能量传递特性。

Linear energy transfer characterization of five gel dosimeter formulations for electron and proton therapeutic beams.

机构信息

Instituto de Física Enrique Gaviola (IFEG), CONICET, Córdoba, Argentina; Laboratorio de Investigación e Instrumentación en Física Aplicada a la Medicina e Imágenes por Rayos X (LIIFAMIR(x)), FAMAF, Universidad Nacional de Córdoba, Argentina; Centro de Física e Ingeniería en Medicina (CFIM) y Depto. de Ciencias Físicas, Universidad de la Frontera, Temuco, Chile.

Laboratorio de Investigación e Instrumentación en Física Aplicada a la Medicina e Imágenes por Rayos X (LIIFAMIR(x)), FAMAF, Universidad Nacional de Córdoba, Argentina.

出版信息

Appl Radiat Isot. 2021 Dec;178:109972. doi: 10.1016/j.apradiso.2021.109972. Epub 2021 Oct 7.

DOI:10.1016/j.apradiso.2021.109972
PMID:34649094
Abstract

Gel dosimeters, including radiochromic types like Fricke, as well as polymer formulations, are considered to be the only reliable option for accurate 3D dosimetry. Nevertheless, their implementation in daily clinical quality assurance still remains strongly limited for a few high specialized radiotherapy centres. Although gel dosimeters present very good water-equivalence due to their inherent chemical and isotopic compositions, addressing the corresponding dosimetry outputs is highly challenging, needing careful assessment in terms of the different radiation qualities involved in the mixed field. Accurate estimations of the linear energy transfer for each gel dosimeter formulation stands as a baseline for further accurate dose deconvolution in mixed radiation fields. The present study reports on the linear energy transfer characterization of five different gel dosimeter formulations, Fricke, Itabis, Magic, Nipam, and Pagat, for electron and proton therapeutic beams as obtained by Monte Carlo approaches, along with experimental results for validation purposes. The linear energy transfer, as a function of beam quality and penetration depth, is obtained for electron and proton therapeutic beams remarking the presence of non-negligible variations, which need to be accounted for a further accurate implementation of gel dosimetry as well as for precise dose deconvolution in mixed radiation fields.

摘要

凝胶体剂量计,包括像 Fricke 这样的光致变色类型,以及聚合物配方,被认为是进行准确 3D 剂量测定的唯一可靠选择。然而,它们在日常临床质量保证中的实施仍然受到少数高专业放疗中心的强烈限制。尽管凝胶体剂量计由于其固有的化学和同位素组成而具有非常好的水等效性,但处理相应的剂量测定结果极具挑战性,需要根据混合场中涉及的不同辐射质量进行仔细评估。对于每种凝胶体剂量计配方,准确估计线性能量传递是在混合辐射场中进行进一步准确剂量反卷积的基础。本研究报告了通过蒙特卡罗方法获得的五种不同凝胶体剂量计配方(Fricke、Itabis、Magic、Nipam 和 Pagat)的线性能量传递特性,用于电子和质子治疗束,以及用于验证目的的实验结果。线性能量传递作为束质量和穿透深度的函数,对于电子和质子治疗束进行了获得,注意到存在不可忽略的变化,这需要在凝胶体剂量计的进一步精确实施以及在混合辐射场中进行精确的剂量反卷积中加以考虑。

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