Macchione Micaela A, Lechón Páez Sofía, Strumia Miriam C, Valente Mauro, Mattea Facundo
Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Av. Haya de la Torre esq. Av. Medina Allende, Córdoba X5000HUA, Argentina.
Centro de Investigaciones y Transferencia de Villa María (CIT Villa María), CONICET-Universidad Nacional de Villa María, Arturo Jauretche 1555, Córdoba X5900LQC, Argentina.
Gels. 2022 Oct 17;8(10):663. doi: 10.3390/gels8100663.
Advances in radiotherapy technology during the last 25 years have significantly improved both dose conformation to tumors and the preservation of healthy tissues, achieving almost real-time feedback by means of high-precision treatments and theranostics. Owing to this, developing high-performance systems capable of coping with the challenging requirements of modern ionizing radiation is a key issue to overcome the limitations of traditional dosimeters. In this regard, a deep understanding of the physicochemical basis of gel dosimetry, as one of the most promising tools for the evaluation of 3D high-spatial-resolution dose distributions, represents the starting point for developing new and innovative systems. This review aims to contribute thorough descriptions of the chemical processes and interactions that condition gel dosimetry outputs, often phenomenologically addressed, and particularly formulations reported since 2017.
在过去25年中，放射治疗技术的进步显著改善了肿瘤的剂量适形性和健康组织的保留，通过高精度治疗和治疗诊断学实现了几乎实时的反馈。因此，开发能够满足现代电离辐射挑战性要求的高性能系统是克服传统剂量计局限性的关键问题。在这方面，深入了解凝胶剂量测定法的物理化学基础，作为评估三维高空间分辨率剂量分布最有前途的工具之一，是开发新型创新系统的起点。本综述旨在全面描述影响凝胶剂量测定输出的化学过程和相互作用，这些通常是从现象学角度进行探讨的，特别是自2017年以来报道的配方。
