Gustavsson Helen, Bäck Sven A J, Medin Joakim, Grusell Erik, Olsson Lars E
Department of Medical Radiation Physics, Lund University, Malmö University Hospital, SE-205 02, Malmö, Sweden.
Phys Med Biol. 2004 Sep 7;49(17):3847-55. doi: 10.1088/0031-9155/49/17/002.
Three-dimensional dosimetry with good spatial resolution can be performed using polymer gel dosimetry, which has been investigated for dosimetry of different types of particles. However, there are only sparse data concerning the influence of the linear energy transfer (LET) properties of the radiation on the gel absorbed dose response. The purpose of this study was to investigate possible LET dependence for a polymer gel dosimeter using proton beam absorbed dose measurements. Polymer gel containing the antioxidant tetrakis(hydroxymethyl)phosphonium (THP) was irradiated with 133 MeV monoenergetic protons, and the gel absorbed dose response was evaluated using MRI. The LET distribution for a monoenergetic proton beam was calculated as a function of depth using the Monte Carlo code PETRA. There was a steep increase in the Monte Carlo calculated LET starting at the depth corresponding to the front edge of the Bragg peak. This increase was closely followed by a decrease in the relative detector sensitivity (Srel = Dgel/Ddiode), indicating that the response of the polymer gel detector was dependent on LET. The relative sensitivity was 0.8 at the Bragg peak, and reached its minimum value at the end of the proton range. No significant effects in the detector response were observed for LET < 4.9 keV microm(-1), thus indicating that the behaviour of the polymer gel dosimeter would not be altered for the range of LET values expected in the case of photons or electrons in a clinical range of energies.
使用聚合物凝胶剂量计可以进行具有良好空间分辨率的三维剂量测定,该剂量计已针对不同类型粒子的剂量测定进行了研究。然而,关于辐射的线能量转移(LET)特性对凝胶吸收剂量响应的影响,仅有稀少的数据。本研究的目的是通过质子束吸收剂量测量来研究聚合物凝胶剂量计可能存在的LET依赖性。含有抗氧化剂四(羟甲基)鏻(THP)的聚合物凝胶用133 MeV单能质子进行辐照,并使用磁共振成像(MRI)评估凝胶吸收剂量响应。使用蒙特卡罗代码PETRA计算单能质子束的LET分布随深度的变化。蒙特卡罗计算得到的LET从对应于布拉格峰前沿的深度开始急剧增加。这种增加紧接着是相对探测器灵敏度(Srel = D凝胶/D二极管)的下降,表明聚合物凝胶探测器的响应取决于LET。在布拉格峰处相对灵敏度为0.8,并在质子射程末端达到最小值。对于LET < 4.9 keV µm⁻¹,未观察到探测器响应有显著影响,因此表明在临床能量范围内光子或电子情况下预期的LET值范围内,聚合物凝胶剂量计的行为不会改变。