Automatic identification of triple negative breast cancer in ultrasonography using a deep convolutional neural network.

Triple negative (TN) breast cancer is a subtype of breast cancer which is difficult for early detection and the prognosis is poor. In this paper, 910 benign and 934 malignant (110 TN and 824 NTN) B-mode breast ultrasound images were collected. A Resnet50 deep convolutional neural network was fine-tuned. The results showed that the averaged area under the receiver operating characteristic curve (AUC) of discriminating malignant from benign ones were 0.9789 (benign vs. TN), 0.9689 (benign vs. NTN). To discriminate TN from NTN breast cancer, the AUC was 0.9000, the accuracy was 88.89%, the sensitivity was 87.5%, and the specificity was 90.00%. It showed that the computer-aided system based on DCNN is expected to be a promising noninvasive clinical tool for ultrasound diagnosis of TN breast cancer.