Department of Reproductive Health and Infertility, Guangdong Women and Children Hospital, 521 Xingnan Avenue, Panyu District, Guangzhou, 511442, China.
Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Sci Rep. 2021 Oct 14;11(1):20490. doi: 10.1038/s41598-021-99850-4.
This study aimed to retrospectively analyse the effect of the baseline luteinising hormone/follicle-stimulating hormone ratio (bLH/FSH) on the live-birth rate per fresh-embryo transfer cycle (LBR/ET) in infertile women with polycystic ovary syndrome (PCOS) who received a fresh-embryo transfer. A total of 424 patients with PCOS who underwent the first cycle of in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) fresh-embryo transfer at our hospital was enrolled. Univariate and multivariate logistic regression analyses, along with curve fitting and a threshold effect analysis, were performed. Baseline LH/FSH levels were a significant (P < 0.05) independent risk factor affecting live birth. In the first IVF/ICSI antagonist treatment cycles, LBR/ET after fresh-embryo transfer was relatively flat, until bLH/FSH was 1.0; thereafter, it started to decrease by 17% for every 0.1-unit bLH/FSH increase. Considering the decline in LBR/ET, it is recommended that PCOS women with bLH/FSH > 1.0 carefully consider fresh-embryo transfer during their first IVF/ICSI.
本研究旨在回顾性分析基础促黄体生成素/卵泡刺激素比值（bLH/FSH）对多囊卵巢综合征（PCOS）不孕患者行新鲜胚胎移植周期活产率（LBR/ET）的影响。纳入我院首次接受体外受精（IVF）/胞浆内单精子注射（ICSI）新鲜胚胎移植的 424 例 PCOS 患者。进行单因素和多因素逻辑回归分析，并进行曲线拟合和阈值效应分析。基础 LH/FSH 水平是影响活产的显著（P<0.05）独立危险因素。在首次 IVF/ICSI 拮抗剂治疗周期中，新鲜胚胎移植后 LBR/ET 相对平坦，直到 bLH/FSH 达到 1.0；此后，bLH/FSH 每增加 0.1 单位，LBR/ET 开始下降 17%。考虑到 LBR/ET 的下降，建议 bLH/FSH>1.0 的 PCOS 女性在首次 IVF/ICSI 中谨慎考虑新鲜胚胎移植。
