Department of General Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China.
Department of General Surgery, East Hospital, Tongji University School of Medicine, Shanghai, China.
Front Endocrinol (Lausanne). 2023 Jan 5;13:1043173. doi: 10.3389/fendo.2022.1043173. eCollection 2022.
Obesity-related ovulation abnormalities (OA) affect fertility. LSG is the most frequent bariatric operation. However, no research has identified a reliable indicator for predicting OA recovery after LSG. The purpose of this research was to examine the prognostic usefulness of preoperative the luteinizing hormone (LH) to follicle-stimulating hormone (FSH) ratio (LFR).
Our department conducted a prospective study from 2016 to 2021. Venous blood was typically tested 3 days before surgery to get the preoperative LFR. Descriptive data, preoperative and postoperative variables were also collected. Binary logistic regression related preoperative LFR with OA recovery. The receiver operating characteristic (ROC) curve evulated preoperative LFR's predictive capability.
A total of 157 women with a complete follow-up of one year were included. LFR was the only factor linked with OA (P < 0.001). AUC (area under the ROC curve) = 0.915, cutoff = 1.782, sensitivity = 0.93, and specificity = 0.82.
Overall, LSG has a favorable surgical result, with a %TWL of 66.082 ± 12.012 at 12 months postoperatively. Preoperative sexual hormone levels, as expressed by LFR, has the potential to predict the fate of OA following LSG at one year post-operatively.
肥胖相关排卵异常（OA）会影响生育能力。LSG 是最常见的减重手术。然而，目前还没有研究确定一种可靠的指标来预测 LSG 后 OA 恢复情况。本研究旨在探讨术前黄体生成素（LH）与卵泡刺激素（FSH）比值（LFR）对预测 LSG 后 OA 恢复的预后价值。
本研究为前瞻性研究，于 2016 年至 2021 年在我院开展。通常在术前 3 天检测静脉血以获取术前 LFR。收集描述性数据、术前和术后变量。采用二元逻辑回归分析术前 LFR 与 OA 恢复的关系。通过受试者工作特征（ROC）曲线评估术前 LFR 的预测能力。
共纳入 157 例术后随访完整的女性，LFR 是唯一与 OA 相关的因素（P<0.001）。AUC（ROC 曲线下面积）=0.915，截点=1.782，敏感性=0.93，特异性=0.82。
总体而言，LSG 手术结果良好，术后 12 个月时的体重减轻率（%TWL）为 66.082±12.012。术前性激素水平（LFR）可能预测 LSG 术后 1 年 OA 的结局。
