Parente F, Lazzaroni M, Petrillo M, Bianchi Porro G
Scand J Gastroenterol Suppl. 1986;122:42-5. doi: 10.3109/00365528609102586.
Colloidal bismuth subcitrate (CBS) in the form of a chewable tablet has been compared with ranitidine in the short-term treatment of benign gastric ulcers. Eighty patients were admitted to this randomised single blind study. Endoscopic control was carried out after 4 weeks, and after 8 weeks when healing was incomplete or had not occurred at the 4-week examination. After 1 month of therapy the healing rates were 70% with CBS and 62.5% with ranitidine (P = not significant). At two months the corresponding cure rates were 87.5% and 79%, respectively (P = not significant). Antacid consumption was higher in the group treated with ranitidine, but the difference was not statistically significant. Patient cooperation was good and similar in the two groups. These findings confirm that CBS, in tablet form, is at least as effective as ranitidine in the acute treatment of benign gastric ulcers.
已将咀嚼片形式的枸橼酸铋钾（CBS）与雷尼替丁用于良性胃溃疡的短期治疗并进行了比较。80名患者被纳入这项随机单盲研究。4周后进行内镜检查，若4周检查时愈合不完全或未发生愈合，则在8周后进行内镜检查。治疗1个月后，CBS组的愈合率为70%，雷尼替丁组为62.5%（P值无统计学意义）。两个月时，相应的治愈率分别为87.5%和79%（P值无统计学意义）。雷尼替丁治疗组的抗酸剂消耗量更高，但差异无统计学意义。两组患者的配合度良好且相似。这些发现证实，片剂形式的CBS在良性胃溃疡的急性治疗中至少与雷尼替丁一样有效。
