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肠道微生物群来源的短链脂肪酸在高血压中的作用

The Role of Short-Chain Fatty Acids of Gut Microbiota Origin in Hypertension.

作者信息

Wu Yeshun, Xu Hongqing, Tu Xiaoming, Gao Zhenyan

机构信息

Department of Cardiology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China.

出版信息

Front Microbiol. 2021 Sep 28;12:730809. doi: 10.3389/fmicb.2021.730809. eCollection 2021.

DOI:10.3389/fmicb.2021.730809
PMID:34650536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8506212/
Abstract

Hypertension is a significant risk factor for cardiovascular and cerebrovascular diseases, and its development involves multiple mechanisms. Gut microbiota has been reported to be closely linked to hypertension. Short-chain fatty acids (SCFAs)-the metabolites of gut microbiota-participate in hypertension development through various pathways, including specific receptors, immune system, autonomic nervous system, metabolic regulation and gene transcription. This article reviews the possible mechanisms of SCFAs in regulating blood pressure and the prospects of SCFAs as a target to prevent and treat hypertension.

摘要

高血压是心脑血管疾病的重要危险因素，其发病涉及多种机制。据报道，肠道微生物群与高血压密切相关。短链脂肪酸（SCFAs）作为肠道微生物群的代谢产物，通过多种途径参与高血压的发生发展，包括特定受体、免疫系统、自主神经系统、代谢调节和基因转录。本文综述了SCFAs调节血压的可能机制以及将其作为预防和治疗高血压靶点的前景。

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