Mehrdad Mahsa, Norouzy Abdolreza, Safarian Mohammad, Nikbakht Hossein-Ali, Gholamalizadeh Maryam, Mahmoudi Mahmoud
Department of Clinical Nutrition and Dietetics, Besat Hospital, Kurdistan University of Medical Sciences Sanandaj, Iran.
Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences Mashhad, Iran.
Am J Transl Res. 2021 Sep 15;13(9):10404-10412. eCollection 2021.
Obesity and weight loss are reported to be associated with immune function. This study aimed to investigate the changes in counts of lymphocytes involved in microbial defense during weight loss in obese women.
This clinical trial involved 29 women with a body mass index (BMI) ≥ 30 kg/m. The intervention group was prescribed a low-calorie diet (600 kcal lower than caloric requirement per day) plus Orlistat (120 mg three times daily). The control group received diet. Anthropometric indices, obesity-related traits, and blood pressure were assessed every three weeks. Metabolic indices and plasma count of lymphocyte subpopulations (CD3, CD4, CD8, CD19, and CD16/56, as well as the ratio of CD4:CD8) were measured at baseline and after the intervention (after 10% weight loss).
After the weight loss, natural killer cells (CD16/56) decreased in the intervention group (P=0.014) even after adapting for all confounders. No significant changes were observed in other immune markers compared to the control group.
Caloric restriction-induced weight loss might independently weaken the antiviral immune defense. Further clinical trials are warranted to better clarify the association between weight loss, calorie restriction, and immunity.
据报道，肥胖和体重减轻与免疫功能有关。本研究旨在调查肥胖女性体重减轻期间参与微生物防御的淋巴细胞计数变化。
这项临床试验纳入了29名体重指数（BMI）≥30kg/m²的女性。干预组被规定采用低热量饮食（比每日热量需求低600千卡）加奥利司他（每日三次，每次120毫克）。对照组接受常规饮食。每三周评估一次人体测量指标、肥胖相关特征和血压。在基线和干预后（体重减轻10%后）测量代谢指标和淋巴细胞亚群（CD3、CD4、CD8、CD19和CD16/56，以及CD4:CD8比值）的血浆计数。
体重减轻后，即使在对所有混杂因素进行校正后，干预组的自然杀伤细胞（CD16/56）仍有所下降（P=0.014）。与对照组相比，其他免疫标志物未观察到显著变化。
热量限制引起的体重减轻可能会独立削弱抗病毒免疫防御。有必要进行进一步的临床试验，以更好地阐明体重减轻、热量限制和免疫之间的关联。
