Greco Salvatore, Fabbri Nicolò, Bella Alessandro, Bonsi Beatrice, Violi Alessandra, Fortunato Valeria, Govoni Maurizio, Graldi Giuseppe, Passaro Angelina
Department of Translational Medicine, University of Ferrara.
Department of General Surgery, Ospedale del Delta, Lagosanto.
Hematol Rep. 2021 Sep 6;13(3):9177. doi: 10.4081/hr.2021.9177.
The current literature still gives a little information about the relationships between the ABO blood group system and the immune response to the virus or the different disease outcomes. Hypothesizing the presence of a predisposition by some blood groups to COVID-19, we searched for differences between patients towards the different outcomes of disease.We enrolled 330 inpatients with a diagnosis of COVID-19, determining both their ABO blood group system and Rh factor, collecting demographic, clinical and laboratory data. We searched for relationships with COVID-19 outcomes within an observation period of 180 days (Intensification of Care - IoC, Inhospital death, 180-days mortality). The most frequent ABO blood group was A (45.8%); a minor part was represented by group O (38.8%), B (11.5%), AB (3.9%). As for the Rh factor, 86.7% of patients were Rh-positive. There were no significant differences between blood groups and Rh factors as for age, length of hospital stays (LoS), or Charlson Comorbidity Index (CCI), nor we found significant relationships between the ABO groups and COVID-19 outcomes. A significant relation was found between AB group and IoC (=0.03) while as for the Rh factor, the patients with Rh factor positive died with less frequency during the stay (=0.03). Cox regression analyses showed substantial differences in the survival functions concerning the Rh factors. The Rh factor seems to be involved in the 180-day prognosis. The survival functions of patients with Rh factor positive show, in fact, significantly better curves when compared to those with Rh factor negative.
目前的文献中关于ABO血型系统与对病毒的免疫反应或不同疾病结局之间的关系所提供的信息仍然很少。假设某些血型对新冠病毒存在易感性，我们研究了患者在疾病不同结局方面的差异。我们招募了330例诊断为新冠病毒感染的住院患者，确定他们的ABO血型系统和Rh因子，并收集人口统计学、临床和实验室数据。我们在180天的观察期内（加强护理 - IoC、院内死亡、180天死亡率）寻找与新冠病毒感染结局的关系。最常见的ABO血型是A型（45.8%）；较小比例的是O型（38.8%）、B型（11.5%）、AB型（3.9%）。至于Rh因子，86.7%的患者为Rh阳性。在年龄、住院时间（LoS）或查尔森合并症指数（CCI）方面，血型和Rh因子之间没有显著差异，我们也未发现ABO血型与新冠病毒感染结局之间存在显著关系。发现AB型与IoC之间存在显著关系（=0.03），而至于Rh因子，Rh因子阳性的患者在住院期间死亡频率较低（=0.03）。Cox回归分析显示，在Rh因子的生存函数方面存在实质性差异。Rh因子似乎与180天预后有关。事实上，与Rh因子阴性的患者相比，Rh因子阳性的患者的生存函数曲线明显更好。
