Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mol Biol Rep. 2022 Jan;49(1):595-603. doi: 10.1007/s11033-021-06799-8. Epub 2021 Oct 15.
Polycystic ovary syndrome (PCOS) and migraine headaches are considered to be common health problems that may share some risk factors. This study aimed to discuss the possible association between migraine headache and polycystic ovary syndrome.
In this narrative review, PubMed, Scopus, Web of Science, and Google Scholar were systematically searched for retrieving and summarizing published studies up to January 2021 to explore the possible interplay between migraine headache and PCOS. We discuss the possible pathways that may explain the association between migraine headaches and PCOS signs/symptoms and complications. While genetic factors have profound effects on the pathogenesis of migraine headaches, sex hormones, including estrogen and progesterone may also play an important role in inducing migraine headaches. Some disorders, such as sleep apnea, amenorrhea, and vascular disease that are more likely to occur in women with PCOS, may cause or exacerbate migraine headaches in women with PCOS.
Future comprehensive studies are needed to investigate the exact underlining mechanisms related to the association between PCOS and migraine headaches.
多囊卵巢综合征（PCOS）和偏头痛被认为是常见的健康问题，它们可能有一些共同的危险因素。本研究旨在探讨偏头痛与多囊卵巢综合征之间的可能联系。
在本叙述性综述中，系统地检索了 PubMed、Scopus、Web of Science 和 Google Scholar，以检索和总结截至 2021 年 1 月发表的研究，以探讨偏头痛和 PCOS 之间可能存在的相互作用。我们讨论了可能解释偏头痛和 PCOS 体征/症状和并发症之间关联的可能途径。虽然遗传因素对偏头痛的发病机制有深远的影响，但雌激素和孕激素等性激素也可能在诱发偏头痛中发挥重要作用。一些在患有 PCOS 的女性中更可能发生的疾病，如睡眠呼吸暂停、闭经和血管疾病，可能会导致或加重患有 PCOS 的女性的偏头痛。
需要进行未来的综合研究，以调查与 PCOS 和偏头痛之间关联相关的确切潜在机制。
